RETINAL CANNABINOID RECEPTOR EXPRESSION AND FUNCTION

视网膜大麻素受体的表达和功能

• 批准号: 2897798
• 负责人: ALEXANDER J STRAIKER
• 金额: $ 2.14万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2897798
• 关键词: Muller's cell; Urodela; age difference; anandamide; calbindin; cannabinoid receptor; cell type; chickens; dopamine receptor; electrophysiology; gap junctions; immunocytochemistry; laboratory mouse; ligands; receptor expression; retina; trabecular meshwork; visual photoreceptor; voltage /patch clamp; zebrafish

DESCRIPTION: (Applicant's Abstract) Cannabinoid receptors, which mediate the effects of the principal psychoactive ingredient of marijuana and hashish, have been found in large numbers throughout the brain. There is now substantial evidence, including immunohistochemical studies I have performed in our laboratory, that they are also present in the retina. The question is where exactly are they, and what are they doing there. The intent of this project is to use immunohistochemical and electrophysiological techniques to determine where in the retina the cannabinoid receptor is expressed and to characterize the function of the putative ligands anandamide and 2-AG via the investigation of several known and likely mechanisms found in other parts of the brain as well as any others suggested by the immunohistochemical studies.

描述：（申请人的摘要） 大麻素受体，介导主的作用 大麻和大麻的精神活性成分已被发现 整个大脑的数字。 现在有大量证据，包括 我在实验室进行的免疫组织化学研究， 也存在于视网膜中。 问题是他们到底在哪里， 他们在那里做什么。 该项目的目的是使用免疫组织化学和 电生理技术以确定视网膜中的位置 表达大麻素受体并表征 假定的配体Anandamide和2-Ag通过研究几个已知的 并可能在大脑的其他部分以及任何机制 其他由免疫组织化学研究提出的。