RETINAL CANNABINOID RECEPTOR EXPRESSION AND FUNCTION

描述：(申请人摘要) 大麻素受体，介导主效应激反应 大麻和大麻的精神活性成分在大量的 大脑中的数字。现在有大量的证据，包括 我在实验室进行的免疫组织化学研究表明，它们 也存在于视网膜中。问题是他们到底在哪里，以及 他们在那里做什么。 这个项目的目的是使用免疫组织化学和 电生理技术来确定视网膜中的哪个部位 大麻素受体的表达，并表征其功能 通过对几个已知的化合物的研究，推测可能的配体是ANANDAME和2-AG 以及在大脑其他部位发现的可能的机制 免疫组织化学研究提出的其他建议。

DESCRIPTION: (Applicant's Abstract) Cannabinoid receptors, which mediate the effects of the principal psychoactive ingredient of marijuana and hashish, have been found in large numbers throughout the brain. There is now substantial evidence, including immunohistochemical studies I have performed in our laboratory, that they are also present in the retina. The question is where exactly are they, and what are they doing there. The intent of this project is to use immunohistochemical and electrophysiological techniques to determine where in the retina the cannabinoid receptor is expressed and to characterize the function of the putative ligands anandamide and 2-AG via the investigation of several known and likely mechanisms found in other parts of the brain as well as any others suggested by the immunohistochemical studies.