RETINAL CANNABINOID RECEPTOR EXPRESSION AND FUNCTION

视网膜大麻素受体的表达和功能

• 批准号: 6174594
• 负责人: ALEXANDER J STRAIKER
• 金额: $ 2.18万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6174594
• 关键词: Muller's cell; Urodela; age difference; anandamide; calbindin; cannabinoid receptor; cell type; chickens; dopamine receptor; electrophysiology; gap junctions; immunocytochemistry; laboratory mouse; ligands; receptor expression; retina; trabecular meshwork; visual photoreceptor; voltage /patch clamp; zebrafish

DESCRIPTION: (Applicant's Abstract) Cannabinoid receptors, which mediate the effects of the principal psychoactive ingredient of marijuana and hashish, have been found in large numbers throughout the brain. There is now substantial evidence, including immunohistochemical studies I have performed in our laboratory, that they are also present in the retina. The question is where exactly are they, and what are they doing there. The intent of this project is to use immunohistochemical and electrophysiological techniques to determine where in the retina the cannabinoid receptor is expressed and to characterize the function of the putative ligands anandamide and 2-AG via the investigation of several known and likely mechanisms found in other parts of the brain as well as any others suggested by the immunohistochemical studies.

描述：（申请人摘要） 大麻素受体，介导的主要作用， 大麻和印度大麻的精神活性成分，已经在大量的 在整个大脑中的数字。 现在有大量证据，包括 我在实验室进行的免疫组织化学研究表明， 也存在于视网膜中。 问题是他们到底在哪里 他们在那里做什么 本项目的目的是使用免疫组织化学和 电生理学技术来确定视网膜中 大麻素受体的表达和表征的功能， 通过研究几种已知的 以及在大脑其他部位发现的可能机制， 另一些则由免疫组化研究提出。