VULNERABLE PLAQUE IDENTIFICATION BY NEAR-IR SPECTROSCOPY

通过近红外光谱法识别易损斑块

• 批准号: 6017734
• 负责人: S E RYAN
• 金额: $ 10万
• 依托单位: INFRAREDX
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-29 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6017734
• 关键词: atherosclerotic plaque; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; catheterization; diagnosis design /evaluation; histology; human tissue; infrared spectrometry; laboratory rabbit; postmortem

We have demonstrated that the near-infrared system can successfully identify vulnerable plaques in aortic specimens from human autopsies. A company InfraReDx, has been formed to develop a catheter, light source, and detector system for clinical use. Because extensive preliminary data are available, we have chosen the Fast Track application. We have the following specific aims: 1. To perform infrared and histology correlations in human coronary artery tissue in approximately 150 specimens from 10 autopsy cases. 2. To develop a near-infrared catheter, light source and detection system for use in rabbits. 3. To utilize the system in a study of 20 cholesterol-fed rabbits to detect vulnerable aortic plaque. We anticipate that we will achieve sensitivity and specificities > 75% to identify plaques in the rabbit study, thus setting the stage for use in patients in Phase II of this application. PROPOSED COMMERCIAL APPLICATIONS: In addition to the identification of vulnerable plaque usage, the spectroscopy method is likely to be of benefit for multiple other diagnostic uses. These include diagnosis of tissue in the lungs, bladder, GI tract, and central nervous system. InfraReDx will develop these applications after the work for detection of vulnerable plaque is completed.

我们已经证明，近红外线系统可以成功地从人体尸检的主动脉标本中识别出易受攻击的斑块。成立了一家公司Infrredx，开发用于临床的导管、光源和探测器系统。由于有大量的初步数据可用，我们选择了Fast Track应用程序。我们有以下具体的目标：1.对10例尸检病例的约150例人体冠状动脉组织进行红外线与组织学的对照研究。2.研制兔用近红外导管、光源及检测系统。3.将该系统应用于20只高脂饮食的兔的研究，以检测易损的主动脉斑块。我们预计，我们将在兔试验中实现识别斑块的灵敏度和特异度&75%，从而为该应用的第二阶段用于患者奠定基础。拟议的商业应用：除了识别易损斑块的用途外，光谱方法很可能对其他多种诊断用途也有好处。这些诊断包括肺、膀胱、胃肠道和中枢神经系统的组织诊断。Infrredx将在检测脆弱斑块的工作完成后开发这些应用程序。