MAGNETIC RESONANCE IMAGING WITH HIGHLY POLARIZED 3HE GAS

高偏振 3HE 气体磁共振成像

• 批准号: 6200798
• 负责人: PAUL L BOGORAD
• 金额: $ 39.26万
• 依托单位: MEDI-PHYSICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-30 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6200798
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; helium; human subject; image enhancement; inert gas; lung imaging /visualization /scanning; magnetic resonance imaging; molecular polarity

Magnetic Imaging Technologies Incorporated (MITI) is developing a technology that utilizes laser hyperpolarized 3He gas for clinical magnetic resonance imaging (MRI). We believe that 3He imaging can be effective for assessing structure and function of the lungs, ear, colon, nose and throat. In particular, hyperpolarized 3He is being routinely used at the University of Virginia Health Science Center to provide diagnostic quality images of the airspaces of the lung. For Phase II, we propose to develop technological improvements necessary to take this product from a prototype to a commercial product. In order to reach this goal we must improve the performance of the polarizer. In particular we must increase the 3He polarization and the rate at which the hyperpolarized 3He is produced. More technological improvements are also necessary in order to make the device more reliable, as well as easy to manufacture, service and use. Furthermore, in order, to make this technology broadly accessible to the largest number of MR imaging centers possible we must develop optimal send receive coil compatible with MR Imagers of different manufacturers. We also plan to develop MR imaging pulse sequences. PROPOSED COMMERCIAL APPLICATIONS: Inert Gas Imaging (IGI) with hyperpolarized 3He is at present being used to produce diagnostic-quality images of the human lung airways. We believe that 3He IGI may be particularly useful for the diagnosis and evaluation of chronic obstructive pulmonary disease (COPD). Hyperpolarized 3He can also be used for imaging of the ear, throat, nose and colon. Inert gas imaging can be made fully compatible with the existing base of 7000 clinical MRI units.

磁成像技术公司（MITI）正在开发一种利用激光超极化3He气体进行临床磁共振成像（MRI）的技术。我们相信，3He成像可以有效地评估肺，耳，结肠，鼻和喉的结构和功能。特别是，超极化3He在弗吉尼亚大学健康科学中心被常规使用，以提供肺部空气空间的诊断质量图像。对于第二阶段，我们建议开发必要的技术改进，使该产品从原型变为商业产品。为了达到这一目标，我们必须提高偏振器的性能。特别是，我们必须增加3He极化和超极化3He产生的速率。还需要进行更多的技术改进，以使该装置更可靠，并易于制造、维修和使用。此外，为了使这项技术广泛地应用于尽可能多的MR成像中心，我们必须开发与不同制造商的MR成像仪兼容的最佳发送接收线圈。我们还计划开发MR成像脉冲序列。拟议的商业应用：超极化3He的惰性气体成像（IGI）目前正用于产生人类肺气道的诊断质量图像。我们认为，3He IGI可能是特别有用的诊断和评估慢性阻塞性肺疾病（COPD）。超极化3He也可用于耳、喉、鼻和结肠的成像。惰性气体成像可以与现有的7000台临床MRI设备完全兼容。