COMPUTERIZED AMPLIFIER/FILTER FOR ELECTROPHYSIOLOGY

用于电生理学的计算机化放大器/滤波器

• 批准号: 2799851
• 负责人: CHAO-SUN E PANG
• 金额: $ 37.9万
• 依托单位: R.C. ELECTRONICS, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2799851
• 关键词: biomedical automation; biomedical equipment development; computer system design /evaluation; electrophysiology; microelectrodes

The development of multi-channel micro-electrodes has allowed researchers to gain a useful understanding of how multitudes of neurons interact and communicate with each other. The micro-electrode technology has provided a logical growth path for the researcher to gather up to 100 channels of data from complex neural networks. However, in order to record 100 channels the researcher at present must go through the tedious task of manually setting up amplifier and filter settings with no way to verify the accuracy and operation of the analog system. In addition, the manually controlled amplifier requires multiple knobs and dials for control and thus takes up a large amount of laboratory space. We propose to develop a low cost, miniature, programmable amplifier and filter that will interface to a preamplifier/electrode setup. This unique design will provide necessary amplification for up to 100 channels and remove any low frequency drifts and electrical noise in advance, plus provide a calibration signal to check the accuracy of the amplifier for data recording devices. The programmability of the system will allow researchers to automate the setup for each experiment without having to depend on memory or tedious manual verification of filter and gain settings. This will provide researchers with precious time to gain more or improved results from each preparation. PROPOSED COMMERCIAL APPLICATION: The micro-electrode created a special demand for a high channel count computer controlled amplifier/filter sub- system in the life science application. No commercial company has developed a simple-to-use, low cost and smaller size programmable amplifier/filter dedicated for this market. The amplifier also has general appeal in the industrial sector for vibration strain and acoustic measurement. It will be an excellent analog front end for other general purpose computer based data acquisition systems, DAT, and analog recording instruments.

多通道微电极的发展使研究人员能够 为了更好地理解神经元之间的相互作用， 互相交流微电极技术提供了 一个合理的增长路径，研究人员收集多达100个渠道， 复杂神经网络的数据。为了记录100 目前研究人员必须完成的繁琐任务是 手动设置放大器和滤波器设置，无法验证 模拟系统的精度和操作。此外，手动 受控放大器需要多个旋钮和刻度盘进行控制， 因此占用大量的实验室空间。我们建议发展一个 低成本、微型、可编程放大器和滤波器， 到电极/电极设置。这种独特的设计将提供 必要的放大多达100个通道，并消除任何低 频率漂移和电气噪声，并提供 校准信号，用于检查放大器的数据精度 记录设备。系统的可编程性将允许 研究人员可以自动化每个实验的设置，而不必 依赖于存储器或繁琐的滤波器和增益的手动验证 设置.这将为研究人员提供宝贵的时间， 每种制剂的效果都有所改善。 拟议的商业应用：微电极创造了一种特殊的 对高通道数计算机控制放大器/滤波器子电路的需求 系统在生命科学中的应用。 没有一家商业公司 开发了一种简单易用，成本低，体积小的可编程 专用于该市场的放大器/滤波器。 该放大器还具有 在工业部门普遍呼吁振动应变和声学 测量. 这将是一个优秀的模拟前端，为其他一般 基于计算机的数据采集系统、DAT和模拟记录 仪器.