课题基金 / 基金详情

RECEPTOR--TYROSINE PHOSPHATASE LAR IN LUNG DEVELOPMENT

RECEPTOR--TYROSINE PHOSPHATASE LAR IN LUNG DEVELOPMENT
受体--酪氨酸磷酸酶 LAR 在肺发育中的作用
批准号:
2857849
负责人:
QIANG YU
金额:
$33.39万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-01-01 至 2000-07-31

项目摘要

项目成果

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中文摘要
翻译
描述(根据申请人的抽象和具体目标改编):
英文摘要
DESCRIPTION (Adapted from the applicant's abstract and specific aims): The goal of this project is to define the role that a specific receptor type tyrosine phosphatase (PTPase) plays in regulating epithelial cell proliferation and differentiation in developing and mature lung. Tyrosine PTPases dephosphorylate phospho-tyrosines on proteins that have been activated or inactivated (phosphorylated) by specific tyrosine kinases of which many are growth factor receptors. Thus, PTPases have the potential to regulate a variety of cell signaling events associated with development and cell differentiation. The application postulates that the transmembrane tyrosine phosphatase LAR may negatively regulate cell growth by interacting with growth factor receptors possessing intrinsic tyrosine kinase activities, and that this function is important in lung epithelial cells, especially during lung development. The specific aims are to: 1) develop methods and reagents to alter biological activities of LAR and define their effects on epithelial cell proliferation and differentiation in a fetal lung organ culture system; 2) determine the potential roles of LAR in regulating cell proliferation and in modulating growth factor-mediated signal transduction; and 3) determine specific mechanism of LAR function by identifying and characterizing proteins with which LAR interacts.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR.
受体样蛋白酪氨酸磷酸酶 LAR 特异性抑制 FGF 诱导的 MAPK 激活。
DOI: 10.1038/sj.onc.1203558
发表时间: 2000
期刊: Oncogene
影响因子: 8
作者: [Wang,X, Weng,LP, Yu,Q]
通讯作者: Yu,Q
Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas.
跨膜酪氨酸磷酸酶 LAR 通过使 p130Cas 去磷酸化和不稳定来诱导细胞凋亡。
DOI: 10.1046/j.1365-2443.1999.00251.x
发表时间: 1999
期刊: Genes to cells : devoted to molecular & cellular mechanisms
影响因子: --
作者: [Weng,LP, Wang,X, Yu,Q]
通讯作者: Yu,Q
Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis.
跨膜酪氨酸磷酸酶 LAR 的过度表达会激活 caspase 途径并诱导细胞凋亡。
DOI: 10.1016/s0960-9822(98)70106-x
发表时间: 1998
期刊: Current biology : CB
影响因子: --
作者: [Weng,LP, Yuan,J, Yu,Q]
通讯作者: Yu,Q
CORE--MOLECULAR BIOLOGY
CORE--MOLECULAR BIOLOGY
FUNCTION OF P130 CAS IN CELL SURVIVAL
FUNCTION OF P130 CAS IN CELL SURVIVAL
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