RECEPTOR--TYROSINE PHOSPHATASE LAR IN LUNG DEVELOPMENT

受体--酪氨酸磷酸酶 LAR 在肺发育中的作用

• 批准号: 2857849
• 负责人: QIANG YU
• 金额: $ 33.39万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2857849
• 关键词: affinity chromatography; biological signal transduction; cell cycle; cell differentiation; cell growth regulation; embryo /fetus tissue /cell culture; flow cytometry; growth /development; growth factor receptors; histocompatibility antigens; laboratory rat; lung; northern blottings; protein tyrosine phosphatase; receptor; respiratory epithelium; tissue /cell culture

DESCRIPTION (Adapted from the applicant's abstract and specific aims): The goal of this project is to define the role that a specific receptor type tyrosine phosphatase (PTPase) plays in regulating epithelial cell proliferation and differentiation in developing and mature lung. Tyrosine PTPases dephosphorylate phospho-tyrosines on proteins that have been activated or inactivated (phosphorylated) by specific tyrosine kinases of which many are growth factor receptors. Thus, PTPases have the potential to regulate a variety of cell signaling events associated with development and cell differentiation. The application postulates that the transmembrane tyrosine phosphatase LAR may negatively regulate cell growth by interacting with growth factor receptors possessing intrinsic tyrosine kinase activities, and that this function is important in lung epithelial cells, especially during lung development. The specific aims are to: 1) develop methods and reagents to alter biological activities of LAR and define their effects on epithelial cell proliferation and differentiation in a fetal lung organ culture system; 2) determine the potential roles of LAR in regulating cell proliferation and in modulating growth factor-mediated signal transduction; and 3) determine specific mechanism of LAR function by identifying and characterizing proteins with which LAR interacts.

描述（根据申请人的抽象和具体目标改编）：

项目成果

Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR.

受体样蛋白酪氨酸磷酸酶 LAR 特异性抑制 FGF 诱导的 MAPK 激活。

• DOI: 10.1038/sj.onc.1203558
• 发表时间: 2000
• 期刊: Oncogene
• 影响因子: 8
• 作者: Wang,X;Weng,LP;Yu,Q
• 通讯作者: Yu,Q

Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas.

跨膜酪氨酸磷酸酶 LAR 通过使 p130Cas 去磷酸化和不稳定来诱导细胞凋亡。

• DOI: 10.1046/j.1365-2443.1999.00251.x
• 发表时间: 1999
• 期刊: Genes to cells : devoted to molecular & cellular mechanisms
• 作者: Weng,LP;Wang,X;Yu,Q
• 通讯作者: Yu,Q

Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis.

跨膜酪氨酸磷酸酶 LAR 的过度表达会激活 caspase 途径并诱导细胞凋亡。

• DOI: 10.1016/s0960-9822(98)70106-x
• 发表时间: 1998
• 期刊: Current biology : CB
• 作者: Weng,LP;Yuan,J;Yu,Q
• 通讯作者: Yu,Q