STRESS REDUCTION AND ATHEROSCLEROTIC CVD IN BLACKS
黑人的压力减轻和动脉粥样硬化性CVD
基本信息
- 批准号:6011899
- 负责人:
- 金额:$ 32.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-03-01 至 2004-06-30
- 项目状态:已结题
- 来源:
- 关键词:African American alternative medicine atherosclerosis behavioral medicine cardiovascular disorder education cardiovascular disorder prevention clinical research clinical trials disease /disorder proneness /risk heart function human subject human therapy evaluation hypertension meditation stress management
项目摘要
The President's Racial and Ethnic Health Disparities Initiative of 1998 emphasizes that African Americans suffer from disproportionately high rates of cardiovascular disease (CVD) morbidity and mortality compared to white Americans. Numerous controlled studies suggest that this disparity is associated with chronic psychosocial and environmental stress. For these reasons, the NHLBI Working Group on Research in Coronary Heart Disease in Blacks has mandated behavior and prevention in this minority population as a national research priority. Our research team has previously demonstrated in NHLBI-supported randomized controlled trials that hypertension can be effectively treated in high risk African Americans with stress reduction using the Transcendental Meditation (TM) program compared to control procedures. These and other studies have also reported clinically significant improvements in other CVD risk factors, psychosocial stress, myocardial ischemia, left ventricular mass and mortality rates from CVD and all-causes in high risk subjects randomized to active stress reduction. Preliminary findings from our recently completed, NHLBI-supported clinical trial of stress reduction in the prevention of hypertensive heart disease in inner city African Americans has indicated that atherosclerotic CVD, assessed by carotid artery intima-media thickness (IMT), significantly regresses after eight months of active stress reduction intervention compared to control education. These results were comparable to effects of lipid lowering therapies or extensive lifestyle modification. This proposed continuation project will extend these findings by investigating the effectiveness of active stress reduction in the secondary prevention of atherosclerotic CVD in African Americans. This five year study will be a randomized, single-blind, controlled, community-based trial involving 184 African American subjects with known coronary heart disease. Male and female subjects will be enrolled at our on-going field site, Martin Luther King-Drew Medical Center in inner city Los Angeles. After baseline testing, subjects will be randomized to either active stress reduction with TM or health education control-both in addition to usual medical care-and posttested after 12 months. The primary outcome will be carotid artery atherosclerosis (IMT) measured non-invasively by quantitative B-mode ultrasonography. Secondary measures will include traditional CVD risk factors (blood pressure, lipids, smoking, exercise), psychosocial stress, quality of life and cost effectiveness. The results of this clinical trial will yield valuable new knowledge for the prevention of CVD through behavioral means in high risk African Americans.
1998年总统的种族和族裔健康差异倡议强调,与白色美国人相比,非裔美国人患心血管疾病的发病率和死亡率高得不成比例。 许多对照研究表明,这种差异与长期的心理社会和环境压力有关。 出于这些原因,NHLBI黑人冠心病研究工作组已将这一少数群体的行为和预防作为国家研究重点。我们的研究团队先前在NHLBI支持的随机对照试验中证明,与对照程序相比,使用超觉静坐(TM)程序可以有效地治疗高风险非洲裔美国人的高血压。 这些和其他研究还报告了随机接受主动减压的高风险受试者的其他CVD风险因素、心理社会应激、心肌缺血、左心室质量和CVD和全因死亡率的临床显著改善。从我们最近完成的,NHLBI支持的临床试验的压力减少在高血压心脏病的预防在内城的非裔美国人的初步结果表明,动脉粥样硬化性心血管疾病,评估颈动脉内膜中层厚度(IMT),显着消退后,8个月的积极减压干预相比,控制教育。 这些结果与降脂治疗或广泛的生活方式改变的效果相当。这个提议的继续项目将通过调查主动减压在非洲裔美国人动脉粥样硬化CVD二级预防中的有效性来扩展这些发现。这项为期五年的研究将是一项随机、单盲、对照、以社区为基础的试验,涉及184名已知患有冠心病的非洲裔美国人。 男性和女性受试者将在我们正在进行的现场研究中心(位于洛杉矶内城的Martin Luther King-Drew Medical Center)入组。 在基线测试后,受试者将被随机分配到TM或健康教育控制的主动减压组,两者都是在常规医疗护理的基础上进行的,并在12个月后进行后测。主要结果是通过定量B型超声无创测量颈动脉粥样硬化(IMT)。次要指标将包括传统的心血管疾病风险因素(血压、血脂、吸烟、运动)、心理社会压力、生活质量和成本效益。 这项临床试验的结果将产生有价值的新知识,通过行为手段预防高风险非洲裔美国人的心血管疾病。
项目成果
期刊论文数量(0)
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ROBERT SCHNEIDER其他文献
ROBERT SCHNEIDER的其他文献
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{{ truncateString('ROBERT SCHNEIDER', 18)}}的其他基金
RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
非裔美国人冠心病二级预防中减压的随机对照试验
- 批准号:
7832549 - 财政年份:2009
- 资助金额:
$ 32.62万 - 项目类别:
RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
非裔美国人冠心病二级预防中减压的随机对照试验
- 批准号:
7937723 - 财政年份:2009
- 资助金额:
$ 32.62万 - 项目类别:
Mechanisms of Meditation in Hypertension in Blacks
冥想治疗黑人高血压的机制
- 批准号:
7405325 - 财政年份:2007
- 资助金额:
$ 32.62万 - 项目类别:
Mechanisms of Meditation in Hypertension in Blacks
冥想治疗黑人高血压的机制
- 批准号:
7798117 - 财政年份:2007
- 资助金额:
$ 32.62万 - 项目类别:
Mechanisms of Meditation in Hypertension in Blacks
冥想治疗黑人高血压的机制
- 批准号:
7211127 - 财政年份:2007
- 资助金额:
$ 32.62万 - 项目类别:
Mechanisms of Meditation in Hypertension in Blacks
冥想治疗黑人高血压的机制
- 批准号:
7672307 - 财政年份:2007
- 资助金额:
$ 32.62万 - 项目类别:
Effects of Herbal Antioxidants on CVD in Older Blacks
草药抗氧化剂对老年黑人心血管疾病的影响
- 批准号:
6666248 - 财政年份:2002
- 资助金额:
$ 32.62万 - 项目类别:
Basic Mechanisms of Meditation and CVD in Older Blacks
老年黑人冥想和心血管疾病的基本机制
- 批准号:
6666246 - 财政年份:2002
- 资助金额:
$ 32.62万 - 项目类别:
Effects of Herbal Antioxidants on CVD in Older Blacks
草药抗氧化剂对老年黑人心血管疾病的影响
- 批准号:
6506222 - 财政年份:2001
- 资助金额:
$ 32.62万 - 项目类别:
Basic Mechanisms of Meditation and CVD in Older Blacks
老年黑人冥想和心血管疾病的基本机制
- 批准号:
6506220 - 财政年份:2001
- 资助金额:
$ 32.62万 - 项目类别:
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