NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
脑损伤后抑郁的神经生物学基础
基本信息
- 批准号:6143038
- 负责人:
- 金额:$ 11.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-15 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:astrocytes bioimaging /biomedical imaging cell death cerebral ischemia /hypoxia clinical depression clinical research comorbidity dendrites dopamine functional ability functional magnetic resonance imaging human subject human tissue immunocytochemistry motor cortex neural plasticity neurochemistry neuropathology norepinephrine oligodendroglia postmortem psychomotor function serotonin stroke
项目摘要
Depression is a serious complication of structural brain injury, and can severely impair physical and cognitive recovery. Of the three million stroke survivors living in the US, more than 65 percent of them will suffer clinical symptoms of depression. Many of these cases can be directly attributable to the stroke, making post-stroke depression a serious health problem. The specific aim of this proposal is to study the biological bases of depression as revealed through patients recovering from ischemic focal brain injury. These studies of depression will focus on its effects on motor system plasticity after middle cerebral artery infarction. We will test the following hypotheses: Motor cortices in clinically depressed subjects will present neurochemical changes in monoaminergic systems (Serotonin, dopamine and noradrenaline). Recovery of motor skills after frontal ischemic stroke depends on the anatomical reorganization of ipsilateral frontal regions adjacent to the infarcted area, and these anatomical changes will be more pronounced in individuals without depression when compared to cases with post-stroke depression. Functional neuroimaging will corroborate the anatomical findings, demonstrating poorer anatomical recovery in depressed patients than in those without depression. Areas underlying functional recovery as seen with fMRI will show the greatest degree of anatomical reorganization when assessed with direct anatomical methods in non-depressed cases compared to depressed ones. The overriding goal of this research is to investigate the neuroanatomical and neuropharmacological differences between depressed and non-depressed patients following focal ishemic brain damage, and to correlate the findings from studies of autopsy tissue with neuroimaging studies using functional magnetic resonance imaging (fMRI). Since combining both methods will limit the number of cases, in parallel, we will perform the same neuroantomical studies in post-mortem tissue with damage in the equivalent areas (but without fMRI assessment). The detection of the changes in cellular circuitry during recovery in groups with and without post-stroke depression will allow us to understand better the neurobiological substrate of this disorder. In the long run, this information may lead to novel pharmacological treatments in both depression and stroke, but most importantly, in those cases where depression is a concomitant of structural brain injury. At the same time, the current research aims to give the principal investigator necessary mentored experience to achieve independence in biological psychiatry research.
抑郁症是结构性脑损伤的严重并发症,可严重损害身体和认知恢复。在美国生活的300万中风幸存者中,超过65%的人会出现抑郁症的临床症状。其中许多病例可直接归因于中风,使中风后抑郁成为严重的健康问题。本研究的具体目的是通过缺血性局灶性脑损伤患者的康复来研究抑郁症的生物学基础。这些研究将集中在抑郁症对大脑中动脉梗死后运动系统可塑性的影响。我们将测试以下假设:临床抑郁症受试者的运动皮质将呈现单胺能系统(血清素,多巴胺和去甲肾上腺素)的神经化学变化。额叶缺血性脑卒中后运动技能的恢复依赖于与梗死区相邻的同侧额叶区域的解剖重组,与脑卒中后抑郁症患者相比,这些解剖变化在无抑郁症患者中更为明显。功能性神经影像学将证实解剖学上的发现,表明抑郁症患者的解剖学恢复比无抑郁症患者差。与抑郁症患者相比,用直接解剖方法评估非抑郁症患者时,fMRI显示的潜在功能恢复区域将显示出最大程度的解剖重组。本研究的主要目的是研究局灶性缺血性脑损伤后抑郁和非抑郁患者的神经解剖学和神经药理学差异,并将尸检组织研究结果与功能磁共振成像(fMRI)的神经影像学研究结果联系起来。由于两种方法的结合将限制病例的数量,因此,我们将在同等区域的死后组织中进行相同的神经解剖研究(但不进行功能磁共振成像评估)。在有和没有中风后抑郁的人群中,检测细胞回路在恢复期间的变化将使我们更好地了解这种疾病的神经生物学基础。从长远来看,这一信息可能会导致抑郁症和中风的新药物治疗,但最重要的是,在那些抑郁症伴随结构性脑损伤的情况下。与此同时,目前的研究旨在为首席研究员提供必要的指导经验,以实现生物精神病学研究的独立性。
项目成果
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ANA SOLODKIN其他文献
ANA SOLODKIN的其他文献
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{{ truncateString('ANA SOLODKIN', 18)}}的其他基金
Mirror Imitation Therapy for Motor Recovery After Stroke
中风后运动恢复的镜像疗法
- 批准号:
8215538 - 财政年份:2007
- 资助金额:
$ 11.25万 - 项目类别:
Mirror Imitation Therapy for Motor Recovery After Stroke
中风后运动恢复的镜像疗法
- 批准号:
7454314 - 财政年份:2007
- 资助金额:
$ 11.25万 - 项目类别:
Mirror Imitation Therapy for Motor Recovery After Stroke
中风后运动恢复的镜像疗法
- 批准号:
7318174 - 财政年份:2007
- 资助金额:
$ 11.25万 - 项目类别:
Mirror Imitation Therapy for Motor Recovery After Stroke
中风后运动恢复的镜像疗法
- 批准号:
7877801 - 财政年份:2007
- 资助金额:
$ 11.25万 - 项目类别:
Mirror Imitation Therapy for Motor Recovery After Stroke
中风后运动恢复的镜像疗法
- 批准号:
7643090 - 财政年份:2007
- 资助金额:
$ 11.25万 - 项目类别:
NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
脑损伤后抑郁的神经生物学基础
- 批准号:
6654996 - 财政年份:1999
- 资助金额:
$ 11.25万 - 项目类别:
NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
脑损伤后抑郁的神经生物学基础
- 批准号:
6391626 - 财政年份:1999
- 资助金额:
$ 11.25万 - 项目类别:
NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
脑损伤后抑郁的神经生物学基础
- 批准号:
6528125 - 财政年份:1999
- 资助金额:
$ 11.25万 - 项目类别:
NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
脑损伤后抑郁的神经生物学基础
- 批准号:
6185781 - 财政年份:1999
- 资助金额:
$ 11.25万 - 项目类别: