REGULATORY MECHANISMS OF OVARIAN PROGESTERONE RECEPTORS

Ok-Kyong Park-Sarge博士被任命为 生理系毕业于1993年7月。她表现得很出色 在过去的18个月里，作为生物医学研究人员的能力。她是 获得了NIH第一个奖项(R29)，并已向两家公司申请了试点资金 马基癌症中心和加州大学老龄中心 肯塔基州。她是美国国立卫生研究院资助的生殖科学培训的成员 计划并积极与Markey癌症中心和 老龄化研究中心。当前，教学和服务活动 约占她努力的50%。在RCDA的支持下，Park博士- 军士长将被免去正式的教学和服务活动，并将 能够集中精力进行或监督研究，包括 指导研究生或博士后研究员。一个重要的 减少她的教学和服务活动也将使朴博士- 中士将获得几项重要技术的研究培训 未来的研究。 Park-Sarge博士的研究重点是 塔河卵巢中的孕激素受体基因。她在调查期间所做的观察 她的博士后训练期，卵巢瞬时表达 排卵前卵泡颗粒细胞孕酮受体基因的表达 在排卵过程的关键时期，清楚地表明 卵巢是黄体酮自分泌或旁分泌作用的靶点。 她进一步确定，监管 孕激素受体基因在这个组织中是通过膜的激活而产生的 促性腺激素受体。因此，这些发现揭示了一个惊人的事实 黄体生成素受体基因调控的差异 卵巢与任何其他含有孕激素受体的组织相比。她 长期目标是更好地了解卵巢孕酮的作用 受体在正常和功能障碍的生育调节中的作用 生殖过程。 她的近期目标是确定 促性腺激素刺激卵巢中孕酮受体转录。 在颁奖期间，她将检查细胞和分子 孕激素受体基因转录的机制。她会决定 蛋白激酶A和C在促性腺激素刺激孕酮中的作用 颗粒细胞受体的表达及顺式调控序列的确定 介导促性腺激素诱导的PR表达。此外，她还将 确定缺乏雌激素刺激的这种激活的基础 吉恩。此外，她还将应用有关青少年公关表达的信息 雌性大鼠到衰老雌性大鼠检查是否有年龄相关性的改变 PR的表达可以解释一些观察到的变化 生殖衰老。她与生殖组织成员的互动 生物学小组、马基癌症中心和华盛顿大学老龄中心 肯塔基大学将帮助她成长为一名 科学界。 肯塔基大学对Park-Sarge博士的坚定承诺 与RCDA一起将在Park-Sarge博士的 未来作为科学界领袖的地位。

Dr. Ok-Kyong Park-Sarge was appointed an Assistant Professor in the Department of Physiology in July 1993. She has demonstrated outstanding competence as a biomedical researcher during the last 18 months. She was awarded an NIH FIRST AWARD (R29) and has applied for pilot funds from both the Markey Cancer Center and the Center on Aging at the University of Kentucky. She is a member of the NIH-funded Reproductive Sciences Training Program and actively interacts with members of the markey Cancer Center and the Center on Aging. At the present time, teaching and service activities comprise about 50% of her effort. With support from an RCDA, Dr. Park- Sarge would be relieved of formal teaching and service activities and would be able to concentrate on the conduct or supervision of research including supervision of graduate students or postdoctoral fellows. A significant reduction in her teaching and service activities would also allow Dr. Park- Sarge to obtain research training in several techniques important for future studies. Dr Park-Sarge's research has focused on the regulatory mechanisms of the progesterone receptor gene in tahe ovary. The observation she made during her postdoctoral training period, that the ovary transiently expresses the progesterone receptor gene in granulosa cells of preovulatory follicles during the period critical for ovulatory processes, clearly suggests that the ovary is a target of autocrine or paracrine action of progesterone. She has further determined that the primary mechanism regulating the progesterone receptor gene in this tissue is through activation of membrane receptors for gonadotropins. Thus, these findings reveal a striking difference between regulation of the progesterone receptor gene int he ovary compared to any other progesterone receptor-containing tissue. Her long-term goal is to better understand athe role of ovarian progesterone receptors in the regulation of fertility in normal and dysfunctional reproductive processes. Her immediate goal is to determine the molecular mechanisms for gonadotropin-stimulated progesterone receptor transcription in the ovary. During the award period, she will examine the cellular and molecular mechanisms of progesterone receptor gene transcription. She will determine the role of protein kinase A and C in gonadotropin-stimulated progesterone receptor expression in granulosa cells and define cis-regulatory sequences that mediate gonadotropin-induced PR expression. In addition, she will determine the basis of the lack of estrogen-stimulated activation of this gene. Moreover, she will apply athe information on PR expression in young female rats to aging female rats to examine whether age-related alterations of PR expression may explain some of the observed changes that occur during reproductive aging. Her interaction with members of the reproductive biology group, the Markey Cancer Center, and the Center on Aging at the University of Kentucky will facilitate her growth as a leader within the scientific community. A strong commitment to Dr. Park-Sarge from the University of Kentucky together with the RCDA will make a critical difference in Dr. Park-Sarge's future status as leader within the scientific community.