DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
批准号:
6044111
负责人:
Michael H Court
金额:
$11.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-08-01 至 2000-07-31
中文摘要
描述(改编自申请人摘要):建议
英文摘要
DESCRIPTION (Adapted from the applicant's abstract): The proposed
research will use biochemical and molecular genetic techniques to
elucidate commonly known, but poorly understood, defects in drug
metabolism that are characteristic of particular species, breeds and
strains of laboratory animals. The primary focus of this project is on
glucuronidation. This knowledge is important to human health not only
from the aspect that it will improve the predictability of the effects
of drugs in animal models of human disease, such as the cat, and perhaps
in preclinical pharmaceutical testing, but also because such animals may
model similar molecular bases for drug glucuronidation deficiency in
certain patients. Clinically, abnormalities in glucoronidation accounts
in part for significantly enhanced toxicity of acetaminophen [Tylenol(R)]
and acetylsalicylic acid (aspirin) in the cat compared with other
species. Similar glucuronidation deficits have been observed in human
patients with Crigler-Najjar syndrome and Gilbert's syndrome (a disease
that is estimated to affect 5-7% of the population). In support of this
research focus, preliminary data from this laboratory suggests that the
cat lacks significant expression of one isoform of UDP-
glucuronyltransferase shown to be defective in Crigler-Najjar syndrome
and possibly Gilbert's syndrome.
期刊论文(6)
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DOI:
--
发表时间:
2001-12
期刊:
The Journal of pharmacology and experimental therapeutics
影响因子:
--
作者:
[M. Court;S. Duan;L. Moltke;D. Greenblatt;C. Patten;J. Miners;P. Mackenzie]
通讯作者:
M. Court;S. Duan;L. Moltke;D. Greenblatt;C. Patten;J. Miners;P. Mackenzie
Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6.
雪貂中的对乙酰氨基酚 UDP-葡萄糖醛酸基转移酶:物种和性别差异以及雪貂 UGT1A6 的序列分析。
DOI:
10.1046/j.1365-2885.2001.00366.x
发表时间:
2001
期刊:
Journal of veterinary pharmacology and therapeutics
影响因子:
1.3
作者:
[Court,MH]
通讯作者:
Court,MH
Diagnostic exercise: infertility in two chimeric mice.
诊断练习:两只嵌合小鼠的不育症。
DOI:
--
发表时间:
1997
期刊:
Laboratory animal science.
影响因子:
--
作者:
[Shomer,NH, Foltz,CJ, Li,X, Fox,JG]
通讯作者:
Fox,JG
Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences.
狗肝微粒体的异丙酚羟基化:测定开发和狗品种差异。
DOI:
--
发表时间:
1999
期刊:
Drug metabolism and disposition: the biological fate of chemicals.
影响因子:
--
作者:
[Court,MH, Hay-Kraus,BL, Hill,DW, Kind,AJ, Greenblatt,DJ]
通讯作者:
Greenblatt,DJ
MicroRNAs as effectors of variable human drug metabolism
-
批准号:8514016
-
项目类别:
-
资助金额:$27.69万
-
财政年份:2012
-
负责人:Michael H Court
-
依托单位:
MicroRNAs as effectors of variable human drug metabolism
-
批准号:8574401
-
项目类别:
-
资助金额:$28.69万
-
财政年份:2012
-
负责人:Michael H Court
-
依托单位:
MicroRNAs as effectors of variable human drug metabolism
-
批准号:8341339
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2012
-
负责人:Michael H Court
-
依托单位:
MicroRNAs as effectors of variable human drug metabolism
-
批准号:8827811
-
项目类别:
-
资助金额:$28.21万
-
财政年份:2012
-
负责人:Michael H Court
-
依托单位:
MicroRNAs as effectors of variable human drug metabolism
-
批准号:8653584
-
项目类别:
-
资助金额:$28.61万
-
财政年份:2012
-
负责人:Michael H Court
-
依托单位:
Acetaminophen Pharmacogenetics
-
批准号:7937349
-
项目类别:
-
资助金额:$18.59万
-
财政年份:2009
-
负责人:Michael H Court
-
依托单位:
Mechanisms of adverse host responses to antibiotics
-
批准号:7054675
-
项目类别:
-
资助金额:$19.96万
-
财政年份:2005
-
负责人:Michael H Court
-
依托单位:
Mechanisms of adverse host responses to antibiotics
-
批准号:6925811
-
项目类别:
-
资助金额:$16.35万
-
财政年份:2005
-
负责人:Michael H Court
-
依托单位:
MOLECULAR DETERMINANTS OF UGT FUNCTION
-
批准号:6525944
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
Acetaminophen Pharmacogenetics
-
批准号:7260086
-
项目类别:
-
资助金额:$28.61万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
MOLECULAR DETERMINANTS OF UGT FUNCTION
-
批准号:6795533
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
MOLECULAR DETERMINANTS OF UGT FUNCTION
-
批准号:6387238
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
MOLECULAR DETERMINANTS OF UGT FUNCTION
-
批准号:6652545
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
MOLECULAR DETERMINANTS OF UGT FUNCTION
-
批准号:6189886
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2000
-
负责人:Michael H Court
-
依托单位:
DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
-
批准号:2281136
-
项目类别:
-
资助金额:$7.94万
-
财政年份:1995
-
负责人:Michael H Court
-
依托单位:
DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
-
批准号:2281135
-
项目类别:
-
资助金额:$7.94万
-
财政年份:1995
-
负责人:Michael H Court
-
依托单位:
DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
-
批准号:2751014
-
项目类别:
-
资助金额:$9.23万
-
财政年份:1995
-
负责人:Michael H Court
-
依托单位:
DEFECTS OF DRUG METABOLISM IN LABORATORY ANIMALS
-
批准号:2460705
-
项目类别:
-
资助金额:$7.94万
-
财政年份:1995
-
负责人:Michael H Court
-
依托单位:
ARRHYTHMIA IN DOGS
-
批准号:3912293
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Michael H Court
-
依托单位:
ARRHYTHMIA IN DOGS
-
批准号:3892906
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Michael H Court
-
依托单位:
海外基金