CONTROL OF RESPIRATORY MOTOR ACTIVITY--ALPHA 2 RECEPTORS

本研究的长期目标是研究α 2- 肾上腺素能受体控制呼吸运动输出和呼吸 节奏研究的主要目的是确定 哪些α 2肾上腺素受体调节呼吸节律，表现为 延髓和脊髓运动神经元传出活动的变化， 特殊的呼吸肌为了实现这一具体目标， 提议，清醒的，站立的山羊模型和氯醛糖麻醉， 人工通气山羊模型将用于测试特定的 与α 2肾上腺素受体控制呼吸运动有关的假说。 α-2激动剂（可乐定或胍那苄）诱导呼吸性心律失常 在清醒的山羊中，由呼吸急促的交替周期组成 和呼吸抑制。在麻醉动物中，双侧 迷走神经切断术和去除外周化学感受器的α 2激动剂诱导 长时间和可变的呼吸暂停。拟议研究的具体目标 是，l）检查迷走神经反馈在发展中的作用， 由α 2-肾上腺素受体激动剂诱导的呼吸不稳定; 2）试验 α_2-肾上腺素能受体差异性控制颅 和脊髓运动神经元活动; 3）检查中枢和 外周（颈动脉体）化学感受机制对运动神经元 活化及其与α 2肾上腺素受体的相互作用。Alpha-2 受体激动剂作为气体麻醉，镇痛， 镇静剂和抗高血压药;然而， 关于这些物质对呼吸影响的现有资料 神经调节药物拟议研究获得的数据将 提供重要信息，说明我们对 α 2肾上腺素能受体在临床上的重要性日益增加， 呼吸生理学

The long term objectives of this study are to examine the role of alpha2- adrenoceptors in the control respiratory motor output and respiratory rhythm. The principal objective of the study is to determine the extent to which alpha2-adrenoceptors modulate respiratory rhythm, manifested as changes of efferent activity from medullary and spinal motoneurons to specific respiratory muscles. To carry out the specific aims of this proposal, the awake, standing goat model and the chloralose-anesthetized, artificially-ventilated goat model will be used to test specific hypotheses related to respiratory motor control by alpha2 adrenoceptors. Alpha-2 agonists (clonidine or guanabenz) induce respiratory arrhythmias in awake goats consisting of alternating periods of tachypneic breathing and respiratory depression. In anesthetized animals with bilateral vagotomy and peripheral chemoreceptors removed alpha2 agonists induce prolonged and variable apneas. The specific aims of the proposed research are to, l) examine the role of vagal feedback in the development of breathing instabilities induced by alpha2-adrenoceptor agonists; 2) test the hypothesis that alpha2-adrenoceptors differentially control cranial and spinal motoneuronal activity; 3) examine the effects of central and peripheral (carotid body) chemosensory mechanisms on motoneuronal activation and their interactions with alpha2 adrenoceptors. Alpha-2 receptor agonists are important as adjuncts to gas anesthesia, analgesia, sedation and anti-hypertensive agents; however, there is little information available concerning the respiratory effects of these neuromodulating drugs. The data obtained by the proposed research will provide important information regarding our knowledge of the role of alpha2 adrenoceptors that have growing clinical significance in respiratory physiology.