Differential respiratory muscle recruitment induced by clonidine in awake goats.
Differential respiratory muscle recruitment induced by clonidine in awake goats.
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可乐定在清醒山羊中诱导的差异性呼吸肌募集。
DOI：
10.1152/jappl.1998.84.4.1198
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Bisgard,GE
中科院分区：
文献类型：
--
作者：
Hedrick,MS;Dwinell,MR;Janssen,PL;Pizarro,J;Bisgard,GE
本研究的目的是检验以下假设：α2 激动剂可乐定引起的呼吸节律障碍伴随着呼吸肌的差异性募集。在成年山羊 (n= 14) 中，肌电图 (EMG) 测量是通过吸气肌（膈肌和胸骨旁肋间肌）和呼气肌 [胸骨三角肌 (TS) 和腹横肌 (Abd)] 进行的。甲杓肌 (TA) 肌电图被用作上呼吸道（声门）通畅的指标。中枢和外周化学感受器刺激增强了所有脊髓吸气和呼气肌肉的峰值肌电图活动。在常氧条件下，阶段性 TA 在呼吸周期的吸气后阶段很明显。在可乐定引起的呼吸节律障碍发作期间，TS 和 Abd 活动减弱或消除，而膈肌和胸骨旁肋间活动则没有变化。呼吸暂停期间 TS 或 Abd EMG 没有强直激活；然而，TA 活动在呼吸暂停期间变得紧张。我们得出结论：1) α2-肾上腺素受体刺激导致呼吸节律失常期间呼吸肌的差异性募集；2) 清醒山羊中呼吸暂停伴随着主动声门关闭。
The purpose of this study was to test the hypothesis that dysrhythmic breathing induced by the α2-agonist clonidine is accompanied by differential recruitment of respiratory muscles. In adult goats (n= 14) electromyographic (EMG) measurements were made from inspiratory muscles (diaphragm and parasternal intercostal) and expiratory muscles [triangularis sterni (TS) and transversus abdominis (Abd)]. EMG of the thyroarytenoid (TA) muscle was used as an index of upper airway (glottal) patency. Peak EMG activities of all spinal inspiratory and expiratory muscles were augmented by central and peripheral chemoreceptor stimuli. Phasic TA was apparent in the postinspiratory phase of the breathing cycle under normoxic conditions. During dysrhythmic breathing episodes induced by clonidine, TS and Abd activities were attenuated or abolished, whereas diaphragm and parasternal intercostal activities were unchanged. There was no tonic activation of TS or Abd EMG during apneas; however, TA activity became tonic throughout the apnea. We conclude that1) α2-adrenoceptor stimulation results in differential recruitment of respiratory muscles during respiratory dysrhythmias and2) apneas are accompanied by active glottic closure in the awake goat.
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影响因子：
2.5
作者：
COHEN, MI
通讯作者：
COHEN, MI
可乐定在阻塞性睡眠呼吸暂停中的作用。
DOI：
--
发表时间：
1992
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
F. Issa
通讯作者：
F. Issa
通气后放电和中枢呼吸驱动清醒山羊的相互作用。
DOI：
10.1152/jappl.1994.76.1.416
发表时间：
1994
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Engwall,MJ;Smith,CA;Dempsey,JA;Bisgard,GE
通讯作者：
Bisgard,GE
赛拉嗪对马通气的影响。
影响因子：
1
作者：
J. Lavoie;John Pascoe;C. Kurpershoek
通讯作者：
C. Kurpershoek
巴比妥类药物引起羔羊呼吸骤停后，声门主动关闭时间延长。
DOI：
10.1016/0034-5687(96)00013-8
发表时间：
1996
期刊：
Respiration physiology
影响因子：
--
作者：
J. Praud;I. Kianicka;V. Diaz;J. Leroux;D. Dalle
通讯作者：
D. Dalle