Precision targeting of mTOR in conventional and MHC class I-restricted anti-tumour CD4+ T cells

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Adoptive immunotherapy is an emerging therapy that has provided exciting preliminary results in some cancer patients. The protocols involve removing immune cells called T cells from patients and then reprogramming them to attack cancer cells. However, early results show that not all patients will respond to the treatment or will later relapse, meaning either that the T cells don't work or that the cancer changes and evades the immune attack. In our laboratory, we are developing methods to broaden the immune attack by including other immune cells. In this project, we will evaluate how modifying a subset of immune cells called CD4+ T cells can improve their ability to target cancer cells following infusion and then, keep working to ensure that the cancer cannot regrow. We intend to use this knowledge to design new approaches for adoptive immunotherapy in patients.