Centre for Integrated research into Musculoskeletal Ageing (CIMA) Renewal

肌肉骨骼老化综合研究中心 (CIMA) 更新

• 批准号: MR/P020941/1
• 负责人: Malcolm Jackson
• 金额: $ 166.97万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP020941%2F1
• 关键词: Centre; Integrated; research; into; Musculoskeletal

OverviewThe MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team. CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp: 1) How our muscles, bones and joints change as we age. 2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis. 3) What each person can do to reduce the risk of developing these problems. Progress So FarCIMA was first funded for 5 years in 2012. CIMA has made great progress in figuring out some key processes in muscles, bones and joints as we age. As well as working out what might reduce the risk of developing these problems, we have also done trials of some likely nutritional agents. These might reduce age-related decline in muscles, bones and joints. We have obtained some early evidence that raising vitamin D may help reduce age-related decline, but putting up nitrate intake may not help. A big limit to expanding research in this important area has also been a lack of well-trained researchers and doctors. So the Centre has also developed and run good training courses to meet this need.Future: Targets, Treatments & TrainingThis bid is for 5 more years of funding from the Medical Research Council (MRC) and Arthritis Research UK to help build on this work. Our first phase of funding has let the CIMA members spot certain changes to cells- called epigenetic changes. These seem vital in influencing whether muscles, bones and joint tissues decline quickly or slowly as we age. We plan to do a linked research programme across Liverpool, Newcastle and Sheffield. This will seek to work out the importance of these changes and whether we can modify the changes to reduce the risk of getting muscle, bone and joint problems. We will also work together to look more closely at whether nutrition and exercise can prevent or reduce the risk of these problems. We also plan to expand our training programme so more basic scientists and doctors can do excellent research into these problems. Key results will be shared in papers and meetings. More funding bids will be made to do this work.Patient ViewPeople with arthritis have helped to shape this bid. By joining a series of "Arthritis Matters" Public Engagement events, for example. These have helped the public grasp CIMA's research and shape future priorities. Above all this includes a grasp of new arthritis treatments and how study findings can benefit patients. We also asked a group of 15 patients to advise on the final lay summary. We think talking to patients often about research and listening to their views makes for better research.Better EngagementGoing forward, patients and the public will continue to be actively involved by providing insight and valued feedback in many ways. Face to face meetings will remain a key part. And more events will be used, including local, national and global schemes. There will be new work with schools, to share CIMA's work, inspire new ideas and nurture talent. The VOICE North digital platform will support this across the Centre and more widely. The CIMA website will also be kept up to date and advances shared on Twitter. We know most older people don't use these yet, but that could change quickly as access gets easier and cheaper. We expect young people to help make solutions for this. We will also increase our work with drug companies, local authorities and the NHS. This will allow us to develop ways to make sure our findings are quickly put into practice to benefit older people. Arthritis is also one of a key number of conditions included in the NIHR James Lind Alliance Priority Setting Partnership on Ageing and Multiple conditions, led by Newcastle University. This will provide more chances for patients who have arthritis to be involved and link to CIMA.

MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing（CIMA）是一个独特的团队。CIMA带来了来自英国三个主要国家的技能组合。大学：利物浦、纽卡斯尔和谢菲尔德。它帮助医生和实验室科学家一起工作，以掌握：1）我们的肌肉，骨骼和关节如何随着年龄的增长而变化。2)这是如何使一些人容易出现这些组织的问题，如关节炎和骨质疏松症。3)每个人都可以做些什么来减少发展这些问题的风险。因此，FarCIMA在2012年首次获得了为期5年的资助。CIMA在研究肌肉、骨骼和关节随着年龄增长的一些关键过程方面取得了很大进展。除了找出可能降低这些问题发生风险的方法外，我们还对一些可能的营养剂进行了试验。这些可能会减少与年龄相关的肌肉，骨骼和关节的衰退。我们已经获得了一些早期证据，表明增加维生素D可能有助于减少与年龄相关的衰退，但增加硝酸盐摄入量可能没有帮助。在这一重要领域扩大研究的一个很大限制也是缺乏训练有素的研究人员和医生。因此，该中心还开发和运行良好的培训课程，以满足这一需要。未来：目标，治疗和培训这一出价是5年以上的资金，从医学研究理事会（MRC）和关节炎研究英国，以帮助建立这项工作。我们的第一阶段资金让CIMA成员发现了细胞的某些变化-称为表观遗传变化。这些似乎对肌肉、骨骼和关节组织随着年龄的增长是快速还是缓慢地衰退至关重要。我们计划在利物浦、纽卡斯尔和谢菲尔德进行一项相关的研究计划。这将寻求找出这些变化的重要性，以及我们是否可以修改这些变化，以减少肌肉，骨骼和关节问题的风险。我们还将共同努力，更密切地关注营养和运动是否可以预防或减少这些问题的风险。我们还计划扩大我们的培训计划，以便更多的基础科学家和医生能够对这些问题进行出色的研究。主要成果将在文件和会议上分享。更多的资金投标将做这项工作。病人视图关节炎的人已经帮助塑造这一出价。例如，通过参加一系列“关节炎问题”公众参与活动。这些都有助于公众掌握CIMA的研究和塑造未来的优先事项。最重要的是，这包括掌握新的关节炎治疗方法以及研究结果如何使患者受益。我们还要求一组15名患者对最终的总结提出建议。我们认为经常与患者讨论研究并听取他们的意见有助于更好的研究。更好的参与展望未来，患者和公众将继续积极参与，以多种方式提供见解和宝贵的反馈。面对面的会议将仍然是一个关键部分。更多的活动将被使用，包括地方，国家和全球计划。将有新的工作与学校，分享CIMA的工作，激发新的想法和培养人才。北方之声数字平台将在整个中心和更广泛的范围内支持这一工作。CIMA网站也将保持最新状态，并在Twitter上分享进展。我们知道大多数老年人还没有使用这些，但随着访问变得更容易和更便宜，这种情况可能会很快改变。我们希望年轻人帮助解决这个问题。我们还将加强与制药公司、地方当局和NHS的合作。这将使我们能够找到方法，确保我们的发现迅速付诸实践，使老年人受益。关节炎也是由纽卡斯尔大学领导的NIHR詹姆斯林德联盟关于老龄化和多种疾病的优先设置伙伴关系中包括的关键疾病之一。这将为患有关节炎的患者提供更多参与并与CIMA联系的机会。

项目成果

DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study

• DOI: 10.1016/j.bone.2024.117051
• 发表时间: 2024-02-22
• 期刊: BONE
• 影响因子: 4.1
• 作者: Aldieri，Alessandra;Paggiosi，Margaret;Terzini，Mara
• 通讯作者: Terzini，Mara

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

• DOI: 10.1002/art.40064
• 发表时间: 2017-05
• 期刊: Arthritis & rheumatology (Hoboken, N.J.)
• 作者: Aggarwal R;Rider LG;Ruperto N;Bayat N;Erman B;Feldman BM;Oddis CV;Amato AA;Chinoy H;Cooper RG;Dastmalchi M;Fiorentino D;Isenberg D;Katz JD;Mammen A;de Visser M;Ytterberg SR;Lundberg IE;Chung L;Danko K;García-De la Torre I;Song YW;Villa L;Rinaldi M;Rockette H;Lachenbruch PA;Miller FW;Vencovsky J;International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation
• 通讯作者: International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation

From quadrupedal to bipedal walking 'on the fly': the mechanics of dynamical mode transition in primates

从四足行走到双足行走“飞翔”：灵长类动物动态模式转换的机制

• DOI: 10.1242/jeb.244792
• 发表时间: 2023
• 期刊: Journal of Experimental Biology
• 影响因子: 2.8
• 作者: Aerts P

Diabetic Neuropathy and Gait: A Review.

• DOI: 10.1007/s13300-017-0295-y
• 发表时间: 2017-12
• 期刊: Diabetes therapy : research, treatment and education of diabetes and related disorders
• 作者: Alam U;Riley DR;Jugdey RS;Azmi S;Rajbhandari S;D'Août K;Malik RA
• 通讯作者: Malik RA