SIMULTANEOUS DUAL ISOTOPE SPECT W/ CROSS TALK CORRECTION

SPECT的一个独特功能是能够使用两种药物 用不同的同位素标记发出不同能量的光子 对不同的生理过程进行同步测量。 同时从两个同位素中获取投影数据具有 优点是它允许测量两个潜在相关的 过程(例如，静息和应激灌流以及受体密度) 同样的时间。这可能会添加其他诊断信息，并且在 此外，还有一些实际的优势，如增加病人 吞吐量、消除与注册有关的问题并导致 两项研究中常见的患者运动。然而，由于分散在 病人和伽马相机和较差的能量分辨率 常规伽马相机，双同位素采集将导致 串扰污染两组投影数据。在这 我们假设我们可以同时为 获取和重建双同位素图像，可以减少 这种串扰的影响到图像具有诊断性的程度 图像质量接近收购后的质量 分开的。我们选择专注于两个特定的应用程序：Dual 核素~(99)m/T1-201负荷/静息心肌灌注SPECT和DUAL 同位素~(99)m/L-123脑SPECT。为此，我们建议：(1) 改进的Tc-99m/T1-201和Tc-99m/I-123采集方法 包括最佳能量窗和相关活动的成像：(2) 开发基于迭代重建的补偿方法以 补偿串扰，包括串扰的准确模型 谈话产生效果：(3)用体模和语模来评价这些方法 结合图像定量测量的仿真实验 质量、数学观察者和人类观察者研究：和(4) 对同时采集和单独采集进行临床评估 双核素静息/负荷心肌灌注成像。在最后 在拟议的资金期限内，我们相信我们将制定 并对可应用于临床的实用方法进行评价。 静息/负荷心肌灌注SPECT的重要应用vt.给出 执行这一程序的频率和重要程度 我们相信，患者舒适度和临床吞吐量都有所改善 这将对临床实践产生重大影响。我们也会 已经开发出同时进行Tc-99m/I-123脑成像的技术 这可能会被证明是重要的，因为新的I-123和Tc-99m标记的脑部药物 都是开发和销售的。

One unique feature of SPECT is the ability to use two pharmaceuticals labeled with different isotopes emiting photons with different energies to make simultaneous measurements of different physiological processes. Simultaneous acquisition of projection data from two isotopes has the advantage that it allows measurement of two potentially related processes (e.g., rest and stress perfusion and receptor density) at the same time. This may add additional diagnostic information and, in addition, there are practical advantages such as increased patient throughput, elimination of problems with registration and results in common patient motion in the two studies. However, due to scatter in the patient and gamma camera and the poor energy resolution of conventional gamma cameras, dual isotope acquisition will result in crosstalk contamination of the two sets of projection data. In this work we hypothesize that we can develop methods for simultaneously acquiring and reconstructing dual isotope images that can reduce the effects of this crosstalk to the point where the images have diagnostic image quality close to that which they would have if acquired separately. We have chosen to focus on two specific applications: dual isotope Tc-99m/T1-201 stress/rest myocardial perfusion SPECT and dual isotope Tc-99m/l-123 brain SPECT. Toward this end we propose to: (1) Develop improved acquisition methods for Tc-99m/T1-201 and Tc-99m/I-123 imaging including optimal energy windows and relative activities: (2) develop iterative reconstruction based compensation methods to compensate for the cross-talk including accurate models for the cross- talk producing effects: (3) to evaluate these methods using phantom and simulation experiments combined with quantitative measures of image quality, mathematical observers and human observer studies: and (4) to perform a clinical evaluation of simultaneous and separate acquisition of dual isotope rest/stress myocardial perfusion imaging. At the end of the proposed funding period we believe that we will have developed and evaluated practical methods that can be applied to the clinically important application of rest/stress myocardial perfusion SPECT. Given the frequency with which this procedure is performed and the significant improvement in both patient comfort and clinical throughput, we believe this would have a substantial impact on clinical practice. We also will have developed techniques for simultaneous Tc-99m/I-123 brain imaging that may prove important as new I-123 and Tc-99m labeled brain agents are developed and marketed.