Chronic Kidney Disease of unknown cause (CKDu) in disadvantaged communities in low-and-middle income countries (LMICs)

中低收入国家 (LMIC) 弱势社区的不明原因慢性肾病 (CKDu)

• 批准号: MR/P02386X/1
• 负责人: Neil Pearce
• 金额: $ 72.99万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP02386X%2F1
• 关键词: Chronic; Kidney; Disease; unknown; cause

There is an epidemic of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low-and-middle income countries (LMICs). This was featured recently in Science which reported previous work of some of the current applicants. Although it is currently unclear whether there is a unified underlying aetiology, these conditions have been collectively termed CKD of unknown cause (CKDu). CKDu is estimated to have led to the premature deaths of tens to hundreds of thousands of young men and women in LMICs over the last two decades. Thus, there is an urgent need to understand the aetiology and pathophysiology of these condition(s) and to develop preventive interventions.Currently it is known that CKDu exists in Central America and mainly affects male rural agricultural workers. It may also be occurring in other tropical/subtropical parts of the world, but standardized data are not available for comparison, and also it is not known which population subgroups it affects. Obtaining this information is an essential step towards discovering the cause(s) of CKDu.We have recently established a partnership involving a practical protocol to estimate distributions of renal function in disadvantaged communities: the Disadvantaged populations estimated glomerular filtration rate (eGFR) epidemiology study (DEGREE). This will provide key information to inform hypotheses and to guide further research into the causes of CKDu. The Foundation Award will enable this partnership to make a step-change by implementing the prevalence survey protocol (and a related validation study) in four centres (India, Malawi, Peru, Mexico) in three tropical/subtropical regions (Asia, Africa, and Latin America) where the disease is likely to be endemic. This will provide the basis for developing further studies to discover the cause(s) of CKDu, and developing interventions to prevent it.

在低收入和中等收入国家（LMICs）的农业社区中，主要是小管间质性慢性肾脏疾病（CKD）的流行。最近，《科学》杂志报道了一些当前申请者的工作。虽然目前尚不清楚是否有一个统一的潜在病因，但这些疾病被统称为不明原因慢性肾病（CKDu）。据估计，在过去二十年中，CKDu导致中低收入国家数万至数十万青年男女过早死亡。因此，迫切需要了解这些疾病的病因和病理生理学，并制定预防措施。目前已知CKDu存在于中美洲，主要影响男性农村农业工人。它也可能发生在世界其他热带/亚热带地区，但没有标准化数据可供比较，也不知道它影响到哪些人口亚群。获得这些信息是发现CKDu病因的关键一步。我们最近建立了一个合作伙伴关系，涉及评估弱势群体肾功能分布的实用方案：弱势群体估计肾小球滤过率（eGFR）流行病学研究（DEGREE）。这将为假设提供关键信息，并指导对CKDu病因的进一步研究。基金会奖将使这一伙伴关系能够通过在该疾病可能流行的三个热带/亚热带地区（亚洲、非洲和拉丁美洲）的四个中心（印度、马拉维、秘鲁和墨西哥）实施患病率调查方案（以及相关的验证研究）来实现逐步改变。这将为进一步研究发现CKDu的病因和制定预防措施提供基础。

项目成果

Challenges of design, implementation, acceptability, and potential for, biomedical technologies in the Peruvian Amazon.

• DOI: 10.1186/s12939-022-01773-7
• 发表时间: 2022-12-19
• 期刊: INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
• 影响因子: 4.8
• 作者: Bressan, Tiana;Valdivia-Gago, Andrea;Silvera-Ccallo, Rosa M.;Llanos-Cuentas, Alejandro;Condor, Daniel F.;Padilla-Huamantinco, Pierre G.;Vilcarromero, Stalin;Miranda, J. Jaime;Zavaleta-Cortijo, Carol
• 通讯作者: Zavaleta-Cortijo, Carol

Additional file 4: of Physical activity and sedentary behavior patterns and sociodemographic correlates in 116,982 adults from six South American countries: the South American physical activity and sedentary behavior network (SAPASEN)

附加文件 4：来自六个南美国家的 116,982 名成年人的体力活动和久坐行为模式与社会人口统计学相关性：南美体力活动和久坐行为网络 (SAPASEN)

• DOI: 10.6084/m9.figshare.9697547
• 发表时间: 2019
• 作者: AndrAŠ Werneck

A secondary analysis examining the concordance of self-perception of weight and actual measurement of body fat percentage: The CRONICAS Cohort Study.

检查自我体重感知与身体脂肪百分比实际测量值的一致性的二次分析：CRONICAS 队列研究。

• DOI: 10.1186/s40608-019-0229-5
• 发表时间: 2019
• 期刊: BMC obesity
• 作者: Bui,AnthonyL;Moscoso,MiguelG;Bernabe-Ortiz,Antonio;Checkley,William;Gilman,RobertH;Smeeth,Liam;Miranda,JJaime
• 通讯作者: Miranda,JJaime

Low prevalence of ideal cardiovascular health in Peru.

• DOI: 10.1136/heartjnl-2017-312255
• 发表时间: 2018-08
• 期刊: Heart (British Cardiac Society)
• 作者: Benziger CP;Zavala-Loayza JA;Bernabe-Ortiz A;Gilman RH;Checkley W;Smeeth L;Malaga G;Miranda JJ;CRONICAS Cohort Study group
• 通讯作者: CRONICAS Cohort Study group

Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study.

• DOI: 10.1186/s12872-021-02405-8
• 发表时间: 2021-12-07
• 期刊: BMC cardiovascular disorders
• 影响因子: 2.1
• 作者: Bazalar-Palacios J;Jaime Miranda J;Carrillo-Larco RM;Gilman RH;Smeeth L;Bernabe-Ortiz A
• 通讯作者: Bernabe-Ortiz A