ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK

青少年医学艾滋病毒/艾滋病研究网络

• 批准号: 2838842
• 负责人: Jeffrey M Birnbaum
• 金额: $ 16.59万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838842
• 关键词: HIV infections; adolescence (12-20); clinical research; female; health care service utilization; human subject; medical outreach /case finding

The Reaching for Excellence in Adolescent Care and Health (REACH) Project is a ulticenter longitudinal study funded by the National Institute of Child Health and Human Development (NICHD), the National Institute of Allergy and Infectious Disease (NIAID), the National Institute on Drug Abuse (NIDA), and the Health Resources and Services Administration (HRSA) to research the medical, biobehavioral, and psychological aspects of HIV/AIDS, including access to care and its use, in adolescents infected with HIV through sexual or drug-taking behaviors. Approximately 240 HIV- positive and 120 HIV-negative subjects, ages 12 through 18 years, will be recruited into this protocol which will measure health status, service utilization, sexual and and drug-taking behaviors, sexually transmitted disease and viral coinfection, and psychological state. Subjects will be seen at three month intervals over the duration of the project. The ultimate goal of this project is to achieve a better understanding of HIV disease progression and co-morbidity in adolescents and thus improve health care management. This goal will be addressed through the initial enrollment of approximately 200 HIV-infected adolescents into a standardized base protocol to characterize population-based spectrum of disease, disease progression, and the effect of co-morbidity with other sexually-transmitted disease and pregnancy in the adolescent population; and the tandardization and evaluation of health care services. The objectives of this project are to examine the pathogenesis of HIV infection, including spectrum of disease, in treated and untreated adolescents ages 12-18 and to ompare the pathogenesis of HIV infection in adolescents to that described for adults and children. To examine the effects of HIV infection on normal physiologic growth and development in HIV-infected adolescents, the morbidity associated with co-infection with sexually transmitted disease that commonly occur in adolescents and to compare these morbidities between HIV-positive and HIV-negative adolescents, the role of mental health on disease progression, and potential immunologic and immunogenetic markers or disease progression specific to adolescents infected with HIV.

青少年关爱与健康追求卓越(REACH)项目 是一项由美国国立卫生研究院资助的多中心纵向研究 儿童健康与人类发展(NICHD)，美国国家健康与人类发展研究所 过敏和传染病(NIAID)，国家药物研究所 滥用(NIDA)和卫生资源和服务管理局(HRSA) 研究…的医学、生物行为和心理学方面 艾滋病毒/艾滋病，包括获得护理及其在受感染青少年中的使用 通过性行为或吸毒行为感染艾滋病毒。大约240名艾滋病病毒感染者- 年龄从12岁到18岁的艾滋病毒阳性和120名艾滋病毒阴性受试者将被 被招募到该方案中，该方案将衡量健康状况、服务 性传播的利用、性和吸毒行为 疾病和病毒的混合感染，以及心理状态。主题将是 在项目持续时间内每隔三个月查看一次。这个 这个项目的最终目标是更好地了解艾滋病毒 青少年的疾病进展和共病，从而改善 医疗保健管理。这一目标将通过最初的 约200名感染艾滋病毒的青少年参加 用于表征基于群体频谱的标准化基本协议 疾病、疾病进展以及与其他疾病共同发病的影响 青少年人口中的性传播疾病和怀孕； 以及卫生保健服务的标准化和评估。这个 该项目的目标是研究艾滋病毒的发病机制。 已治疗和未治疗的感染情况，包括疾病谱 12-18岁青少年与中国青少年HIV感染发病机制比较 青少年对成人和儿童的描述。要检查 HIV感染对儿童正常生理生长发育的影响 感染艾滋病毒的青少年，与艾滋病合并感染的发病率 性传播疾病，通常发生在青少年和 比较HIV阳性和HIV阴性患者的发病率 青少年，心理健康在疾病进展中的作用，以及 潜在的免疫和免疫遗传标记物或疾病进展 专门针对感染艾滋病毒的青少年。