ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK

青少年医学艾滋病毒/艾滋病研究网络

• 批准号: 6211955
• 负责人: Jeffrey M Birnbaum
• 金额: $ 18.68万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6211955
• 关键词: HIV infections; adolescence (12-20); clinical research; female; health care service utilization; human subject; medical outreach /case finding

The Reaching for Excellence in Adolescent Care and Health (REACH) Project is a ulticenter longitudinal study funded by the National Institute of Child Health and Human Development (NICHD), the National Institute of Allergy and Infectious Disease (NIAID), the National Institute on Drug Abuse (NIDA), and the Health Resources and Services Administration (HRSA) to research the medical, biobehavioral, and psychological aspects of HIV/AIDS, including access to care and its use, in adolescents infected with HIV through sexual or drug-taking behaviors. Approximately 240 HIV- positive and 120 HIV-negative subjects, ages 12 through 18 years, will be recruited into this protocol which will measure health status, service utilization, sexual and and drug-taking behaviors, sexually transmitted disease and viral coinfection, and psychological state. Subjects will be seen at three month intervals over the duration of the project. The ultimate goal of this project is to achieve a better understanding of HIV disease progression and co-morbidity in adolescents and thus improve health care management. This goal will be addressed through the initial enrollment of approximately 200 HIV-infected adolescents into a standardized base protocol to characterize population-based spectrum of disease, disease progression, and the effect of co-morbidity with other sexually-transmitted disease and pregnancy in the adolescent population; and the tandardization and evaluation of health care services. The objectives of this project are to examine the pathogenesis of HIV infection, including spectrum of disease, in treated and untreated adolescents ages 12-18 and to ompare the pathogenesis of HIV infection in adolescents to that described for adults and children. To examine the effects of HIV infection on normal physiologic growth and development in HIV-infected adolescents, the morbidity associated with co-infection with sexually transmitted disease that commonly occur in adolescents and to compare these morbidities between HIV-positive and HIV-negative adolescents, the role of mental health on disease progression, and potential immunologic and immunogenetic markers or disease progression specific to adolescents infected with HIV.

追求卓越青少年护理和健康 (REACH) 项目 是一项由国家研究所资助的多中心纵向研究 国家儿童健康与人类发展研究所 (NICHD) 美国国家药物研究所过敏和传染病 (NIAID) 滥用行为 (NIDA) 以及卫生资源和服务管理局 (HRSA) 研究医学、生物行为和心理方面 感染艾滋病毒/艾滋病的青少年，包括获得护理及其使用 通过性行为或吸毒行为感染艾滋病毒。 大约 240 名 HIV- 年龄在 12 岁至 18 岁之间的 HIV 阳性受试者和 120 名 HIV 阴性受试者将被 招募加入该协议，该协议将衡量健康状况、服务 利用、性行为和吸毒行为、性传播 疾病和病毒合并感染以及心理状态。 科目将是 在项目期间每隔三个月查看一次。这 该项目的最终目标是更好地了解艾滋病毒 青少年的疾病进展和共病，从而改善 医疗保健管理。 这一目标将通过最初的 大约 200 名感染艾滋病毒的青少年入读 标准化基础协议来表征基于人群的频谱 疾病、疾病进展以及与其他疾病共病的影响 青少年群体中的性传播疾病和怀孕； 以及医疗保健服务的标准化和评估。 这 该项目的目标是检查艾滋病毒的发病机制 已治疗和未治疗的感染，包括疾病谱 12-18 岁青少年并比较 HIV 感染的发病机制 青少年与成人和儿童所描述的相同。要检查 HIV感染对正常生理生长发育的影响 感染艾滋病毒的青少年，与同时感染艾滋病毒相关的发病率 常见于青少年的性传播疾病 比较 HIV 阳性和 HIV 阴性之间的发病率 青少年，心理健康对疾病进展的作用，以及 潜在的免疫学和免疫遗传学标记或疾病进展 专门针对感染艾滋病毒的青少年。