BREAST CANCER SURVEILLANCE RESEARCH IN NORTH CAROLINA

北卡罗来纳州乳腺癌监测研究

• 批准号: 2895488
• 负责人: BONNIE C YANKASKAS
• 金额: $ 77.07万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2895488
• 关键词: bioimaging /biomedical imaging; breast neoplasms; cooperative study; female; human subject; mammography; mass screening

DESCRIPTION: (Applicant's Description) The specific aims of this research are: 1) To compare mammography screening practice, clinical management, and screening outcomes for the women over age 40 in the 24 county population with special reference to differences in Black versus White, urban versus rural, <50 versus >50, and the subset of women receiving mammography funded through the BCCCP versus the general population of screened women for the years 1995-2000; and 2) To describe the distribution and mammographic characteristics of benign pathology by race, age, and other characteristics to raise hypotheses for further research. Two additional projects are proposed based on the identification of interval and screen detected cancers in this population. The specific aims of these projects are: 1) to assess the image quality of the mammograms of interval cancers compared to screen detected cancers; and 2) to compare the histochemical characteristics of interval versus screen detected cancers. The creation of a population based mammography registry in 24 counties in eastern North Carolina. a population that has a high proportion of Black and rural women, gives us the opportunity to do breast cancer surveillance research using the data collected from 79 mammographic practices in this area. This data is linked to a population based pathology database, and the North Carolina Central Cancer Registry (NC CCR). Analyses will be conducted on the population accrued by the Carolina Mammography Registry for the time period January 1995 through December 2000. Women will be enumerated beginning with their screening mammogram, and their outcomes will be determined through two mechanisms: 1) radiologic follow up from registry linked data; and 2) follow up efforts aimed at the referring physicians. Chi square analyses will be carried out testing proportional data; t tests will be used for comparisons of means; and logistic regression analyses will be carried out when appropriate.

描述：（申请人的描述）本发明的具体目的是： 研究内容：1）比较乳腺X线摄影筛查实践、临床 管理和筛查结果为40岁以上的妇女在24 县人口，特别是黑人与 白色，城市与农村，<50 versus >50岁，以及妇女的子集 接受乳房X光检查通过BCCCP与一般 1995-2000年接受筛查的妇女人数; 2）描述 乳腺良性病变的分布及X线特点 种族，年龄和其他特征，以提出进一步的假设， research. 根据查明的下列项目，提议增加两个项目： 间隔和筛查在该人群中检测到的癌症。具体 这些项目的目的是：1）评估图像质量的 与筛查检测到的癌症相比，间隔期癌症的乳房X线照片;以及 2)比较间隔与筛选的组织化学特征 检测癌症 在24个县建立基于人口的乳房X线摄影登记处 位于北卡罗来纳州东部。一个人口中有很高比例的 黑人和农村妇女，给了我们做乳腺癌的机会 使用79例乳腺X线检查收集的数据进行的监测研究 这方面的做法。该数据与基于人口的 病理学数据库和北卡罗来纳州中央癌症登记处（NC CCR）。将对由 卡罗莱纳乳房X线摄影登记研究，时间范围为1995年1月至 2000年12月。妇女将在筛查开始时被点算 乳房X光检查，其结果将通过两种机制确定： 1)登记研究关联数据的放射学随访;和2）随访 针对转诊医生的努力。卡方分析将是 进行比例数据检验; t检验将用于 将进行平均值比较和逻辑回归分析 适当的时候出来。