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ASPECTS OF UTERINE RECEPTIVITY FOR IMPLANTATION

ASPECTS OF UTERINE RECEPTIVITY FOR IMPLANTATION
子宫植入容受性的各个方面
批准号：
2838778
负责人：
Sudhansu K Dey
金额：
$26.67万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
项目状态：
已结题
起止时间：
1992-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/2838778
关键词：
biomarker cytochrome oxidase embryo implantation enzyme induction /repression fatty acid biosynthesis gene mutation gene targeting genetically modified animals isozymes laboratory mouse leukotrienes lipoxygenase menstrual cycle prostaglandin E prostaglandin F

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中文摘要
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英文摘要
DESCRIPTION: (Adapted from Applicant's Description) The investigators propose to examine further the roles of Prostaglandins (PGs) catalyzed by cyclooxygenases (COX-1 and COX-2) during various phases of uterine receptivity using mice mutated for the COX-1 or COX-2 gene. They also plan to examine whether leukotrienes (LTs) alone or with PGs play any roles in implantation. The specific aims are to examine: (1) the expression of COX-1 and COX-2, and levels of PGs in the periimplantation uteri of wild-type, heterozygous or homozygous mice mutated for the COX-2 and COX-1 genes, respectively, (2) the expression of PG receptors, and (3) of (COX) 5-lipoxygenase (5-LO) and levels of LTs in the periimplantation uteri of these mice, as well as (4) role of PGs/LTs in the attainment of uterine receptivity for implantation.
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Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
  • 批准号：
    8319101
  • 项目类别：
  • 资助金额：
    $1.4万
  • 财政年份：
    2012
  • 负责人：
    Sudhansu K Dey
  • 依托单位：
    NEW YORK ACADEMY OF SCIENCES
PTEN-C0X2-mT0R SIGNALING IN ENDOMETRIAL CANCER
Molecular signaling in uterine receptivity to implantation
Molecular signaling in uterine receptivity to implantation
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