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ASPECTS OF UTERINE RECEPTIVITY FOR IMPLANTATION

ASPECTS OF UTERINE RECEPTIVITY FOR IMPLANTATION
子宫植入容受性的各个方面
批准号：
6125700
负责人：
Sudhansu K Dey
金额：
$27.47万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
项目状态：
已结题
起止时间：
1992-12-01 至 2001-11-30
来源：
https://reporter.nih.gov/project-details/6125700
关键词：
biomarker cytochrome oxidase embryo implantation enzyme induction /repression fatty acid biosynthesis gene mutation gene targeting genetically modified animals isozymes laboratory mouse leukotrienes lipoxygenase menstrual cycle prostaglandin E prostaglandin F

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中文摘要
翻译
描述：(根据申请者的描述改编)调查人员 建议进一步研究前列腺素(PGs)在 环氧合酶(COX-1和COX-2)在子宫不同时期的表达 使用COX-1或COX-2基因突变的小鼠的感受性。他们还计划 为了研究白三烯(LT)是否单独或与PG一起在 植入。具体目的是为了检查：(1)表达 COX-1、COX-2及前列腺素在围植入期子宫中的表达 野生型、杂合子或纯合子小鼠的COX-2和COX-1基因突变 基因：(2)PG受体的表达；(3)(COX) 围植入期子宫组织中5-脂氧合酶(5-LO)和LTS水平的变化 这些小鼠以及(4)PGs/LTS在获得子宫中的作用 对植入的接受性。
英文摘要
DESCRIPTION: (Adapted from Applicant's Description) The investigators propose to examine further the roles of Prostaglandins (PGs) catalyzed by cyclooxygenases (COX-1 and COX-2) during various phases of uterine receptivity using mice mutated for the COX-1 or COX-2 gene. They also plan to examine whether leukotrienes (LTs) alone or with PGs play any roles in implantation. The specific aims are to examine: (1) the expression of COX-1 and COX-2, and levels of PGs in the periimplantation uteri of wild-type, heterozygous or homozygous mice mutated for the COX-2 and COX-1 genes, respectively, (2) the expression of PG receptors, and (3) of (COX) 5-lipoxygenase (5-LO) and levels of LTs in the periimplantation uteri of these mice, as well as (4) role of PGs/LTs in the attainment of uterine receptivity for implantation.
期刊论文(51)
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会议论文
Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice.
雌性小鼠生殖中环氧合酶 1 和环氧合酶 2 功能的药理学和/或遗传破坏的比较分析。
DOI： 10.1210/endo.142.7.8307
发表时间： 2001
期刊： Endocrinology
影响因子： 4.8
作者： [Reese,J, Zhao,X, Ma,WG, Brown,N, Maziasz,TJ, Dey,SK]
通讯作者： Dey,SK
Distribution of transforming growth factor alpha precursors in the mouse uterus during the periimplantation period and after steroid hormone treatments.
在植入期间和类固醇激素治疗后，转化生长因子α前体在小鼠子宫中的分布。
DOI： 10.1095/biolreprod50.3.481
发表时间： 1994
期刊： Biology of reproduction
影响因子： 3.6
作者： [Paria,BC, Das,SK, Huet-Hudson,YM, Dey,SK]
通讯作者： Dey,SK
Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation.
DOI： 10.1210/jcem.84.9.5980
发表时间： 1999-09
期刊： The Journal of clinical endocrinology and metabolism
影响因子： --
作者： [R. Leach;Reda Khalifa;N. Ramirez;S. Das;Jue Wang;S. Dey;R. Romero;D. Armant]
通讯作者： R. Leach;Reda Khalifa;N. Ramirez;S. Das;Jue Wang;S. Dey;R. Romero;D. Armant
Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice.
DOI： 10.1210/mend.14.8.0498
发表时间： 2000-08
期刊： Molecular endocrinology
影响因子： --
作者： [Haengseok Song;H. Lim;S. Das;B. Paria;S. Dey]
通讯作者： Haengseok Song;H. Lim;S. Das;B. Paria;S. Dey
共 20 条
    Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
    • 批准号：
      8319101
    • 项目类别：
    • 资助金额：
      $1.4万
    • 财政年份：
      2012
    • 负责人：
      Sudhansu K Dey
    • 依托单位：
      NEW YORK ACADEMY OF SCIENCES
    PTEN-C0X2-mT0R SIGNALING IN ENDOMETRIAL CANCER
    Molecular signaling in uterine receptivity to implantation
    Molecular signaling in uterine receptivity to implantation
    海外基金