A Global Network for Neglected Tropical Diseases

被忽视的热带病全球网络

基本信息

  • 批准号:
    MR/P027989/1
  • 负责人:
  • 金额:
    $ 861.99万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2017
  • 资助国家:
    英国
  • 起止时间:
    2017 至 无数据
  • 项目状态:
    已结题

项目摘要

It is estimated that ~1 in 6 of the world's population suffer from a Neglected Tropical Disease (NTD) representing a significant challenge to global human health and well-being and this has been recognised by the United Nations (UN). One of the primary aims of the UN's Sustainable Development Goal on "Health and Well-Being" is to "ensure health and well-being for all" and with 1.7 billion people in 185 countries requiring treatment for at least one NTD in 2014, advances in the development of new medicines for NTDs is critical. Indeed, the target set by the UN is "By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases." Supporting the delivery of this goal are many world-wide ventures directed towards the treatment of AIDs (e.g. The Global Fund), tuberculosis (e.g. The Global Fund) and malaria (e.g. Medicines for Malaria Venture) but there is currently no corresponding world-wide sustained effort for NTDs. It is this gap that our global NTD network will fill and, in doing so, will contribute to the delivery of the UN's goal on "Health and Well-Being".Within the spectrum of NTD pathogens, insect-borne parasites represent a major threat to human health across the developing world. In particular, leishmaniasis and Chagas disease represent a significant challenge for developing nations with lower levels of research investment and infrastructure exacerbated by a lack of suitably trained personnel capable of developing much needed solutions. With over 350 million people world-wide considered at risk, more than 1.7M new cases each year, 12 million people currently infected and an economic cost that can be estimated in terms of 2.4 million Disability Adjusted Life Years (DALYs), the health challenge of leishmaniasis is undeniable. A similar situation exists for Chagas disease where there are currently 10M people infected and, in Latin America alone, Chagas disease leads to approx.700,000 (DALYs), nearly six times the socioeconomic toll of malaria in the region. Globally, the total annual economic effect of Chagas disease is estimated at over $7 billion. The challenge presented by these disease states is heightened by the fact that the few efficacious drugs currently available often exhibit serious, potentially fatal, side-effects, and have difficult and prolonged modes of administration leading to poor patient compliance within developing nations. Moreover, reports of resistance to even the most modern drugs are beginning to emerge. We will establish a "Global Network For Neglected Tropical Diseases" which will bring together over 50 academics and more that 500 researchers at 14 institutes around the world all working towards the common goals of delivering scientific advances that will help to combat Leishmaniasis and Chagas disease
据估计,世界人口中约有六分之一患有被忽视的热带病(NTD),这对全球人类健康和福祉构成了重大挑战,这一点已得到联合国(UN)的认可。联合国可持续发展目标关于“健康和福祉”的主要目标之一是“确保所有人的健康和福祉”,2014年,185个国家的17亿人需要至少一种NTD的治疗,NTD新药开发的进展至关重要。事实上,联合国设定的目标是“到2030年,消除艾滋病、结核病、疟疾和被忽视的热带疾病的流行,防治肝炎、水传播疾病和其他传染病。“支持实现这一目标的是许多针对艾滋病(如全球基金)、结核病(如全球基金)和疟疾(如疟疾药物风险投资公司)治疗的全球性企业,但目前没有相应的全球性持续努力来治疗NTD。我们的全球NTD网络将填补这一空白,并在此过程中为实现联合国“健康与福祉”目标做出贡献。在NTD病原体范围内,虫媒寄生虫是发展中国家人类健康的主要威胁。特别是,利什曼病和恰加斯病对发展中国家来说是一个重大挑战,这些国家的研究投资和基础设施水平较低,缺乏能够开发急需解决方案的受过适当培训的人员。全世界有超过3.5亿人被认为处于危险之中,每年有超过170万新病例,目前有1200万人感染,经济成本可以用240万残疾调整生命年(DIMs)来估计,利什曼病的健康挑战是不可否认的。查加斯病也存在类似的情况,目前有1000万人感染,仅在拉丁美洲,查加斯病就导致约70万人(Dabas),几乎是该地区疟疾社会经济死亡人数的六倍。在全球范围内,南美锥虫病每年造成的总经济影响估计超过70亿美元。这些疾病状态所带来的挑战由于以下事实而加剧:目前可用的少数有效药物通常表现出严重的、潜在致命的副作用,并且具有困难和长期的给药模式,导致发展中国家内患者依从性差。此外,甚至对最现代药物的耐药性报告也开始出现。我们将建立一个“被忽视的热带病全球网络”,将世界各地14个研究所的50多名学者和500多名研究人员聚集在一起,共同致力于实现帮助防治利什曼病和恰加斯病的科学进步的共同目标

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Leishmania donovani Impedes Antileishmanial Immunity by Suppressing Dendritic Cells via the TIM-3 Receptor.
  • DOI:
    10.1128/mbio.03309-21
  • 发表时间:
    2022-08-30
  • 期刊:
  • 影响因子:
    6.4
  • 作者:
  • 通讯作者:
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.
Alpha-tubulin acetylation in Trypanosoma cruzi : a dynamic instability of microtubules is required for replication and cell cycle progression
克氏锥虫中的α-微管蛋白乙酰化:复制和细胞周期进展需要微管的动态不稳定性
  • DOI:
    10.1101/2020.12.15.422917
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Alonso V
  • 通讯作者:
    Alonso V
Genome deletions to overcome the directed loss of gene function in Leishmania.
Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression.
  • DOI:
    10.3389/fcimb.2021.642271
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Alonso VL;Carloni ME;Gonçalves CS;Martinez Peralta G;Chesta ME;Pezza A;Tavernelli LE;Motta MCM;Serra E
  • 通讯作者:
    Serra E
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Paul Denny其他文献

Empowering Education with LLMs - The Next-Gen Interface and Content Generation
通过法学硕士赋能教育——下一代界面和内容生成
First Things First: Providing Metacognitive Scaffolding for Interpreting Problem Prompts
首先要事:为解释问题提示提供元认知支架
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Prather;Raymond Pettit;Brett A. Becker;Paul Denny;Dastyni Loksa;Alani L. Peters;Zachary Albrecht;Krista Masci
  • 通讯作者:
    Krista Masci
Decoding Logic Errors: A Comparative Study on Bug Detection by Students and Large Language Models
解码逻辑错误:学生和大型语言模型错误检测的比较研究
Instructor Perceptions of AI Code Generation Tools - A Multi-Institutional Interview Study
教师对人工智能代码生成工具的看法——多机构访谈研究
Exploring the Difficulty of Faded Parsons Problems for Programming Education
探讨帕森斯褪色问题对编程教育的难度

Paul Denny的其他文献

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{{ truncateString('Paul Denny', 18)}}的其他基金

MRC IAA 2021 Durham University
MRC IAA 2021 杜伦大学
  • 批准号:
    MR/X502947/1
  • 财政年份:
    2022
  • 资助金额:
    $ 861.99万
  • 项目类别:
    Research Grant
Mining for new drug and vaccine targets in Toxoplasma gondii sphingolipid biosynthesis - applications in animal and human health
弓形虫鞘脂生物合成中新药和疫苗靶点的挖掘——在动物和人类健康中的应用
  • 批准号:
    BB/T003987/1
  • 财政年份:
    2019
  • 资助金额:
    $ 861.99万
  • 项目类别:
    Research Grant
Sphingolipid biosynthesis in the parasitic apicomplexan protozoa: divergent enzymes in key host:pathogen interactions
寄生顶复门原生动物中的鞘脂生物合成:关键宿主中的不同酶:病原体相互作用
  • 批准号:
    BB/M024156/1
  • 财政年份:
    2016
  • 资助金额:
    $ 861.99万
  • 项目类别:
    Research Grant
Toxoplasma: Sphingolipids in host-parasite interactions syntheses versus scavenging
弓形虫:宿主-寄生虫相互作用中的鞘脂合成与清除
  • 批准号:
    BB/D52396X/1
  • 财政年份:
    2006
  • 资助金额:
    $ 861.99万
  • 项目类别:
    Research Grant

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