EXTENDED ECONOMIC IMPACT ASSESSMENT OF AIDS INTERVENTION

艾滋病干预措施的扩展经济影响评估

• 批准号: 2876566
• 负责人: ANKE RICHTER
• 金额: $ 8.93万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2876566
• 关键词: AIDS education /prevention; behavioral /social science research tag; epidemiology; high risk behavior /lifestyle; human data; mathematical model; model design /development; social model; socioeconomics; substance abuse epidemiology; substance abuse related behavior; substance abuse related disorder

DESCRIPTION: (Adapted from the Applicant's Abstract) This small grant application to the National Institute on Drug Abuse (NIDA) requests support for a secondary analysis of the economic impact of behavioral interventions currently implemented by the North Carolina Cooperative Agreement for AIDS Community-Based Outreach, Intervention, and Research (the NC CoOp study). The principal investigator, Dr. Anke Richter, requests these funds under the priority category of a new and less-experienced research investigator. The proposed effort will continue her dissertation work related to the economic assessment of interventions introduced to prevent the spread of HIV/AIDS in a high-risk population. Mathematical modeling provides a means of estimating epidemic progression and the ultimate outcomes of short-term behavioral interventions. Furthermore, the impact of future behavioral changes, such as possible relapses in HIV risk behavior after an intervention has been completed, can only be assessed via a model. Mathematical disease modeling permits us to link the observable short-term results with important long-term outcomes and permits important "what-if" analysis to assess the impact of small changes in disease or behavioral parameters. Combining a mathematical epidemic model that captures both the number of seroconversions and the time at which they occur with an economic model will enhance the economic analyses. The results will be more detailed and more accurate, thereby permitting a fuller comparison between intervention options. This proposal has three specific aims in performing an extensive economic impact analysis of the interventions implemented by the NC CoOp study: 1. Model the long-term effects (focusing on the number of HIV seroconversions and the time at which they occur) of the interventions implemented by the NC CoOp study on the urban, high- risk, primarily African-American, substance abusing community as a whole. 2. Identify the parameters (such as individual HIV risk behaviors) to which the mathematical epidemic and economic models are most sensitive and thereby identify targets for future policy and intervention programs for substance abusers. 3. Conduct a direct assessment of the cost/savings of the HIV interventions for substance abusers by incorporating a full epidemic model into the economic model.

描述：（改编自申请人的摘要）这项向国家药物滥用研究所 (NIDA) 提出的小额赠款申请请求支持对北卡罗来纳州艾滋病社区外展、干预和研究合作协议（NC CoOp 研究）目前实施的行为干预措施的经济影响进行二次分析。首席研究员安克·里克特 (Anke Richter) 博士根据一位经验不足的新研究研究员的优先类别请求这些资金。拟议的工作将继续她的论文工作，该论文涉及对为防止艾滋病毒/艾滋病在高危人群中传播而采取的干预措施进行经济评估。数学模型提供了一种估计流行病进展和短期行为干预的最终结果的方法。此外，未来行为变化的影响，例如干预完成后艾滋病毒危险行为可能复发，只能通过模型​​进行评估。数学疾病模型使我们能够将可观察的短期结果与重要的长期结果联系起来，并允许重要的“假设”分析来评估疾病或行为参数的微小变化的影响。将捕获血清转化数量及其发生时间的数学流行病模型与经济模型相结合将增强经济分析。结果将更详细、更准确，从而可以对干预方案进行更全面的比较。该提案有三个具体目标，即对 NC CoOp 研究实施的干预措施进行广泛的经济影响分析： 1. 模拟 NC CoOp 研究实施的干预措施对整个城市、高风险、主要是非裔美国人的药物滥用社区的长期影响（重点关注 HIV 血清转化的数量及其发生时间）。 2. 确定数学流行病和经济模型最敏感的参数（例如个人艾滋病毒危险行为），从而确定未来针对药物滥用者的政策和干预计划的目标。 3. 通过将完整的流行病模型纳入经济模型，对药物滥用者的艾滋病毒干预措施的成本/节省进行直接评估。