MURINE DEVELOPMENTAL BRAIN INJURY

描述：(改编自申请者的描述) 应用描述了发育中的小鼠将被 结扎所致单侧脑缺氧缺血 一条颈总动脉，然后暴露于全身 吸入浓度降低的氧气造成的缺氧。在.期间 特异性脑缺氧缺血的病程及继发 将进行实验，以确定其性质和范围 最终的组织损伤。具体的治疗干预措施还包括 建议。其他发育中的小鼠将受到兴奋性毒性损伤 通过将谷氨酸激动剂注射到大脑中选定的区域。 与缺氧-缺血研究一样，建议进行以下实验 也要确定最终形态异常的程度 作为治疗干预的效果。

DESCRIPTION: (Adapted from applicant's description) This revised application describes experiments in which developing mice will be subjected to unilateral cerebral hypoxia-ischemia produced by ligation of one common carotid artery followed thereafter by exposure to systemic hypoxia by the inhalation of reduced concentrations of oxygen. During the course of and following the cerebral hypoxia-ischemia, specific experiments will be performed to ascertain the nature and extent of the ultimate tissue injury. Specific therapeutic interventions also are proposed. Other developing mice will be subjected to excitotoxic injury by the injection of glutamate agonists into selected areas of brain. As with the hypoxia-ischemia studies, experiments are proposed to ascertain the extent of the ultimate morphologic abnormalities as well as the effect of therapeutic interventions.