Real-time state of vigilance monitor for the neonatal intensive care unit
新生儿重症监护病房实时警戒状态监测
基本信息
- 批准号:10053394
- 负责人:
- 金额:$ 38.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAlgorithmic SoftwareAlgorithmsAwardBehavioralBottle feedingCaffeineCaringChildClinicalClinical ResearchClinical TrialsCuesCustomDataData AnalysesData ScientistDevelopmentDevicesDoseElectroencephalographyEquipmentEventFeedsFrequenciesFundingGoalsHealthHealth ProfessionalHealth Services AccessibilityImprove AccessIndustryInfantInfant HealthIntensive CareInterruptionInterventionIntervention StudiesInterviewKnowledgeLeadLiquid substanceManualsMeasuresMedicineMethadoneMiddle InsomniaMonitorNeonatalNeonatal Intensive Care UnitsNeurologyNewborn InfantOutcomePerformancePharmaceutical PreparationsPhasePolysomnographyPrincipal InvestigatorProspective cohortPublishingResearchResearch PersonnelScientistSecureSleepSleep FragmentationsSleep StagesSleep disturbancesStandardizationTechnologyTestingTimeTranslatingTranslational ResearchTranslationsUnited StatesWorkalgorithm developmentawakebasecare deliveryclinical careclinical practicedata acquisitiondata qualitydesignexperiencefeedinghealingimprovedinterestneonateneurodevelopmentprematurepreventprogramsprospectiveprototypereal time monitoringrespiratorysleep quantitytoolverification and validationvigilance
项目摘要
Abstract
Approximately one out of ten children born in the United States are admitted to the neonatal intensive care unit
(NICU). Sleep is essential to healthy development, and researchers are investigating how to improve sleep.
One major barrier to good sleep in the NICU is the frequent interruptions the infants receive. Adjusting these
interruptions based on whether the infant is asleep and what state of sleep could improve sleep and thus
improve healthy development. However, it is generally not possible to tell if an infant in the NICU is awake or
asleep, as the behavioral repertoire is very limited as these young ages and may be further influenced by other
health conditions. Furthermore, few centers have the equipment and clinical expertise to assess and analyze
sleep in neonates. Thus, there is a critical need to develop technology which could provide real-time
assessment of whether neonates are awake or asleep, as well as the stage of sleep. The overall goal of this
proposal is to address that need by creating a real-time monitor of sleep-wake stage for neonates in the NICU.
The project will additionally gather preliminary data about the device’s utility. These data include comparing
feeding efficacy between cases where the infant is awoken to feed versus already being awake, influence of
interruptions to sleep, and sleep changes related to medications received. This project benefits from two
principal investigators, one an expert in neonatal clinical practice and research and the other a data scientist
with experience developing algorithms for long term clinical neuromonitoring. Specific Aims in the R61 phase
of the award include 1) developing a working prototype and conducting initial testing and verification and 2)
acquiring initial use-case and pre-market data. The R33 phase of the award allows for prospective validation
and verification. The immediate, expected outcome is the verified, validated device and preliminary use-case
data, allowing this proposal to be directly followed by clinical research regarding how changes in practice
based on real-time knowledge of sleep can improve care in the NICU. The expected, long term outcome will be
a commercial device allowing translation of that research into clinical practice.
摘要
在美国出生的儿童中,大约十分之一被送入新生儿重症监护室
(新生儿重症监护病房)。睡眠对健康发育至关重要,研究人员正在研究如何改善睡眠。
NICU中良好睡眠的一个主要障碍是婴儿经常受到干扰。调整这些
根据婴儿是否睡着以及睡眠状态可以改善睡眠,
促进健康发展。然而,通常不可能判断NICU中的婴儿是否清醒,
睡眠,因为这些年轻人的行为能力非常有限,可能会受到其他因素的进一步影响。
健康状况。此外,很少有中心拥有设备和临床专业知识来评估和分析
新生儿睡眠因此,迫切需要开发能够提供实时通信的技术。
评估新生儿是醒着还是睡着,以及睡眠阶段。总的目标是
建议是通过为NICU中新生儿创建睡眠-觉醒阶段实时监测器来解决该需求。
该项目还将收集有关该设备实用性的初步数据。这些数据包括比较
婴儿被唤醒进食与已经醒来进食的情况之间的喂养功效,
睡眠中断,以及与接受的药物有关的睡眠变化。该项目得益于两个
主要研究者,一位是新生儿临床实践和研究专家,另一位是数据科学家
具有开发长期临床神经监测算法的经验。R61阶段的具体目标
该奖项包括1)开发一个工作原型,并进行初步测试和验证,2)
获取初始用例和上市前数据。该奖项的R33阶段允许前瞻性验证
和核查。直接的预期结果是经过验证、确认的设备和初步用例
数据,使这一建议直接遵循临床研究如何改变实践
基于睡眠的实时知识可以改善NICU的护理。预期的长期结果将是
一种商业设备,可以将该研究转化为临床实践。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JOHN D BARKS', 18)}}的其他基金
Real-time state of vigilance monitor for the neonatal intensive care unit
新生儿重症监护病房实时警戒状态监测
- 批准号:
10505279 - 财政年份:2022
- 资助金额:
$ 38.04万 - 项目类别:
Drug Repurposing to Accelerate Progress in Neonatal Neuroprotection
药物再利用加速新生儿神经保护的进展
- 批准号:
10300790 - 财政年份:2021
- 资助金额:
$ 38.04万 - 项目类别:
Drug Repurposing to Accelerate Progress in Neonatal Neuroprotection
药物再利用加速新生儿神经保护的进展
- 批准号:
10454287 - 财政年份:2021
- 资助金额:
$ 38.04万 - 项目类别:
Real-time state of vigilance monitor for the neonatal intensive care unit
新生儿重症监护病房实时警戒状态监测
- 批准号:
10252927 - 财政年份:2020
- 资助金额:
$ 38.04万 - 项目类别:
Sleep-disordered breathing in infants with myelomeningocele
脊髓脊膜膨出婴儿的睡眠呼吸障碍
- 批准号:
10532367 - 财政年份:2020
- 资助金额:
$ 38.04万 - 项目类别:
Repurposing Azithromycin for Neonatal Neuroprotection
重新利用阿奇霉素进行新生儿神经保护
- 批准号:
9766343 - 财政年份:2018
- 资助金额:
$ 38.04万 - 项目类别:
Maternal Diet and Susceptibility to Neonatal Brain Injury
母亲饮食与新生儿脑损伤的易感性
- 批准号:
8509896 - 财政年份:2013
- 资助金额:
$ 38.04万 - 项目类别:
Maternal Diet and Susceptibility to Neonatal Brain Injury
母亲饮食与新生儿脑损伤的易感性
- 批准号:
8685297 - 财政年份:2013
- 资助金额:
$ 38.04万 - 项目类别:
Docosahexaenoic Acid (DHA) and Neonatal Neuroprotection.
二十二碳六烯酸 (DHA) 和新生儿神经保护。
- 批准号:
8191805 - 财政年份:2011
- 资助金额:
$ 38.04万 - 项目类别:
Docosahexaenoic Acid (DHA) and Neonatal Neuroprotection.
二十二碳六烯酸 (DHA) 和新生儿神经保护。
- 批准号:
8307279 - 财政年份:2011
- 资助金额:
$ 38.04万 - 项目类别:
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