Selection and Transmission of Antimicrobial Resistance in Complex Systems

选择和传播是抗菌素耐药性在全球传播的关键决定因素。抗生素耐药性的这些决定因素经常在实验室环境中进行研究，而实际上它们发生在复杂的系统中，例如在人类和动物肠道或环境生态系统中定植的微生物群落中。STARCS（复杂系统中抗菌素耐药性的选择和传播）的中心目标是从“同一个健康”的角度描述和量化复杂（生态）系统中抗菌素耐药性基因和耐药细菌的选择和传播过程，并将这些因素整合到预测数学模型中，这将用于为政策制定提供信息。STARCS将发展技术突破，以评估抗性基因、可移动遗传因素、细菌、人-动物-环境界面和临床环境的选择和传播动态。该项目将为抗菌素耐药性的选择和传播提供重要的知识，将为科学界提供研究复杂系统中抗菌素耐药性的选择和转移的新工具，并将为国际和国家机构的决策提供急需的指导。最终，STARCS的结果将为制定旨在遏制抗菌素耐药性蔓延的新法规奠定基于证据的基础。

Selection and transmission are key determinants for the dissemination of antimicrobial resistance (AMR) across the planet. These determinants of AMR are frequently studied in laboratory settings while in reality they occur in complex systems, e.g. in microbial communities that colonize human and animal guts or in environmental ecosystems. The central aim of STARCS (Selection and transmission of Antimicrobial Resistance in Complex Systems) is to characterize and quantify the processes of selection and transmission of AMR genes and drug-resistant bacteria in complex (eco)systems from a 'One Health' perspective and to integrate these elements into predictive mathematical models, which will be used to inform policy development. STARCS will develop technological breakthroughs to assess selection and transmission dynamics on the level of the resistance gene, the mobile genetic element, the bacterium, the human-animal-environment interface and in clinical settings. This project will deliver important knowledge into selection and transmission of AMR, will provide the scientific community with novel tools to study selection and transfer of AMR in complex systems and will result in much-needed guidance towards policy decisions by international and national institutions. Ultimately the results from STARCS will form an evidence-based foundation for the development of new regulations, aimed at curbing the spread ofAMR.