Selection and Transmission of Antimicrobial Resistance in Complex Systems

选择和传播是抗菌素耐药性(AMR)在全球传播的关键决定因素。AMR的这些决定因素经常在实验室环境中进行研究，而实际上它们发生在复杂的系统中，例如在定植于人和动物肠道的微生物群落中或在环境生态系统中。STARCS(复杂系统中抗菌素耐药性的选择和传播)的中心目标是从一个健康的角度描述和量化AMR基因和耐药细菌在复杂系统(ECO)中的选择和传播过程，并将这些要素整合到预测数学模型中，用于指导政策制定。STARS将开发技术突破，在抗性基因、可移动遗传元件、细菌、人-动物-环境界面和临床环境的水平上评估选择和传播动力学。该项目将为AMR的选择和传递提供重要的知识，为科学界研究复杂系统中AMR的选择和转移提供新的工具，并将为国际和国家机构的决策提供亟需的指导。最终，STARS的结果将为制定旨在遏制AMR传播的新法规奠定循证基础。

Selection and transmission are key determinants for the dissemination of antimicrobial resistance (AMR) across the planet. These determinants of AMR are frequently studied in laboratory settings while in reality they occur in complex systems, e.g. in microbial communities that colonize human and animal guts or in environmental ecosystems. The central aim of STARCS (Selection and transmission of Antimicrobial Resistance in Complex Systems) is to characterize and quantify the processes of selection and transmission of AMR genes and drug-resistant bacteria in complex (eco)systems from a 'One Health' perspective and to integrate these elements into predictive mathematical models, which will be used to inform policy development. STARCS will develop technological breakthroughs to assess selection and transmission dynamics on the level of the resistance gene, the mobile genetic element, the bacterium, the human-animal-environment interface and in clinical settings. This project will deliver important knowledge into selection and transmission of AMR, will provide the scientific community with novel tools to study selection and transfer of AMR in complex systems and will result in much-needed guidance towards policy decisions by international and national institutions. Ultimately the results from STARCS will form an evidence-based foundation for the development of new regulations, aimed at curbing the spread ofAMR.