Escherichia coli ST131: a model for high-risk transmission dynamics of antimicrobial resistance

本项目将对接大量跨国学术资源，调查大肠杆菌ST131克隆的传播成功情况。大肠杆菌是全世界尿路和血液感染最常见的原因。世卫组织最近的一份报告指出，对使用最广泛的一类抗生素（氟喹诺酮类抗生素[FQs]）的耐药性非常普遍。在世界许多地方，FQs现在对一半以上的患者无效。单一大肠杆菌克隆ST131是造成全球FQ-R和头孢菌素-r大流行的主要原因，每年造成数百万例抗生素耐药感染。目前尚不清楚ST131的哪些特征导致了2000年代最大的抗微生物药物耐药性成功。我们建议一个欧洲-加拿大联合财团来研究ST131的传播动力学。本研究将探讨耐药和毒力基因的垂直和水平传播，以及它们如何促成ST131在人类、动物和不同环境中的成功传播。广泛的目标是通过更好地了解如何处理由耐多药大肠杆菌引起的感染来改善人类健康。该研究将探索ST131高传播率和成功的解释。这是史蒂芬·霍金的名言；“智力是适应变化的能力”。ST131能迅速适应环境变化；我们需要知道原因和方式。这个项目将作为一个模型，预测随着细菌中不断出现耐多药克隆，未来可能会发生什么。

This project will connect a large number of transnational academic resources to investigate the transmission success of the Escherichia coli ST131 clone. E. coli is the most common cause of urinary tract and bloodstream infections worldwide. A recent WHO report states that resistance to one of the most widely used antibiotic classes (fluoroquinolones [FQs]) is very widespread. In many parts of the world, FQs are now ineffective in more than half of patients. A single E. coli clone, ST131, is predominantly responsible for this global FQ-R and cephalosporin-R pandemic causing millions of antibiotic-resistant infections annually. It remains unclear which features of ST131 had resulted in the biggest antimicrobial resistance succes of the 2000s. We propose a combined European-Canadian consortium that will investigate the transmission dynamics of ST131. This study will explore the vertical and horizontal transmission of resistance and virulence genes and how they contributed to the transmission success of ST131 among humans, animals and different environments. The broad goal is to improve human health by better understanding managing infections due to multidrug resistant E. coli. The study will explore explanations for the high transmission rates and success of ST131. A famous quote from Stephen Hawking; "Intelligence is the ability to adapt to change". ST131 adapted rapidly to environmental changes; we need to know why and how. This project will serve as a model to predict what can possibly happen in the future with the continuing emergence of multidrug resistant clones among bacteria.