HORMONAL CONTROL OF HUMAN TESTICULAR FUNCTION

这项工作的总体目标是仔细定义内分泌。 维持男性正常睾丸功能所需的环境。在……里面 特别是，我们关注的是促性腺激素和类固醇环境 刺激人类精子发生所必需的。我们将在实验中 控制正常人睾丸的荷尔蒙环境 确定对精子发生的综合影响。更确切地说， 这项工作的目标是回答四个问题： 1.促性腺激素释放激素(GnRH) 拮抗剂加睾酮(T)抑制促性腺激素分泌和 从而精子发生得更完全，那T独行吗？ 2.T是否转化为双氢睾酮(DHT)，即5α 减少，在刺激人类精子发生中很重要？ 3.T转化为雌二醇(E_2)，即芳构化，重要吗 在人类精子生产的控制中？ 4.超生理促卵泡激素的作用是什么 卵泡刺激素(FSH)对人体睾丸功能的刺激？ 这项工作将利用新的化合物，如促性腺激素释放激素拮抗剂和 5α还原酶抑制剂用于探索正常生理调控 人类睾丸功能系统。我们的研究直接与 安全、有效、可逆的男性治疗方法的发展 避孕和治疗患有精神障碍的男性 精子发生。

The general objective of this work is to define carefully the endocrine milieu that is required to maintain normal testicular function in men. In particular, we are concerned with the gonadotropin and steroid environment necessary to stimulate human spermatogenesis. We will be experimentally manipulating the hormonal environment of the testis in normal men and determining the resultant effects on spermatogenesis. More specifically, the objectives of this work are to answer four questions: 1. Can the combination of a gonadotropin-releasing hormone (GnRH) antagonist plus testosterone (T) suppress gonadotropin secretion and thereby spermatogenesis more completely that can T alone? 2. Is the conversion of T to dihydrotestosterone (DHT) i.e. 5alpha reduction, important in the stimulation of human spermatogenesis? 3. Is the conversion of T to estradiol (E2), i.e. aromatization, important in the control of human sperm production? 4. What is the effect of supraphysiologic follicle-stimulating hormone (FSH) stimulation on human testicular function? This work will make use of new compounds, such as a GnRH antagonist and a 5alpha reductase inhibitor for exploring the normal physiologic control systems of human testicular function. Our studies are directly relevant to the development of safe, effective, reversible methods of male contraception and to the treatment of men with disorders of spermatogenesis.