HORMONAL CONTROL OF HUMAN TESTICULAR FUNCTION

人类睾丸功能的激素控制

• 批准号: 6296771
• 负责人: WILLIAM J BREMNER
• 金额: $ 16.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6296771
• 关键词: blood chemistry; clinical research; fertility; follicle stimulating hormone; gonadotropins; hormone inhibitor; hormone regulation /control mechanism; human subject; immunologic assay /test; luteinizing hormone; male; recombinant proteins; spermatogenesis; spermatogenesis inhibitor; steroid hormone metabolism; testis; testosterone; testosterone 5 alpha reductase

The general objective of this work is to define carefully the endocrine milieu that is required to maintain normal testicular function in men. In particular, we are concerned with the gonadotropin and steroid environment necessary to stimulate human spermatogenesis. We will be experimentally manipulating the hormonal environment of the testis in normal men and determining the resultant effects on spermatogenesis. More specifically, the objectives of this work are to answer four questions: 1. Can the combination of a gonadotropin-releasing hormone (GnRH) antagonist plus testosterone (T) suppress gonadotropin secretion and thereby spermatogenesis more completely that can T alone? 2. Is the conversion of T to dihydrotestosterone (DHT) i.e. 5alpha reduction, important in the stimulation of human spermatogenesis? 3. Is the conversion of T to estradiol (E2), i.e. aromatization, important in the control of human sperm production? 4. What is the effect of supraphysiologic follicle-stimulating hormone (FSH) stimulation on human testicular function? This work will make use of new compounds, such as a GnRH antagonist and a 5alpha reductase inhibitor for exploring the normal physiologic control systems of human testicular function. Our studies are directly relevant to the development of safe, effective, reversible methods of male contraception and to the treatment of men with disorders of spermatogenesis.

这项工作的总目标是仔细定义内分泌 维持男性正常睾丸功能所需的环境。 在 我们特别关注促性腺激素和类固醇环境 是刺激人类精子生成所必需的 我们将实验性地 操纵正常男性睾丸的激素环境， 确定对精子发生的最终影响。 更具体地说， 这项工作的目标是回答四个问题： 1. 促性腺激素释放激素（GnRH） 拮抗剂加睾酮（T）抑制促性腺激素分泌， 从而使精子发生更完全，可以单独T？ 2. 是T转化为双氢睾酮（DHT），即5 α 减少，重要的刺激人类精子发生？ 3. T转化为雌二醇（E2），即芳构化，重要吗 控制人类精子的产生 4. 超生理促卵泡激素的作用是什么 (FSH)刺激人类睾丸功能 这项工作将利用新的化合物，如GnRH拮抗剂和 用于探索正常生理控制的5 α还原酶抑制剂 人类睾丸功能系统。 我们的研究直接关系到 开发安全、有效、可逆的男性避孕方法 避孕和治疗男性生殖系统疾病 精子发生