MODE OF ACTION OF REPRODUCTIVE HORMONES

这个中心已经存在并非常活跃了20多年。 在过去的筹资期间(1991-1995年)，培训了约20名学前教育人员。 博士后和临床研究员通过该中心 活动。该中心的参与者在 发表了60多篇科学论文和评论。许多新进展 在过去的供资期间，在外地发生了多起事件。本中心 续签申请提出续签五个重点项目 关于生殖激素和生殖激素作用机制的新方面 对生殖过程的调节。两个项目涉及 孕激素受体与孕激素对基因的作用机制 两个项目涉及雄激素诱导的基因和基因产物； 其中一个项目涉及受体和促性腺激素的作用机制。 行动。这些项目是我们现有中心的新扩展 程序。D·O·托夫特博士担任主任，T·C·斯佩尔斯伯格博士担任联合- 导演。是次续期申请的项目顺序如下 以下是： 项目1 Spelsberg博士染色质受体站点 孕激素 项目2 Toft博士的分离和鉴定 孕激素受体 项目3 Tindall博士对早期生长发育的描述 前列腺细胞中的反应基因 项目4罗氏博士的结构和功能研究 促性腺激素受体

This Center has been in existence and very active for over 20 years. During the past funding period (1991-1995) the training of about 20 pre- and post-Ph.D. students and clinical fellows has occurred via the Center activities. The Center participants have been productive with the publication of over 60 scientific articles and reviews. Many new advances in the field have occurred during the past funding period. This Center renewal application proposes the continuation of five projects that focus on novel aspects of the mechanism of action of reproductive hormones and the regulation of reproductive processes. Two projects concern the progesterone receptor and the mechanism of progestin action on gene expression; two projects concern androgen-induced genes and gene products; and one project relates to receptors and the mechanism of gonadotropin action. These projects represent new extensions of our existing center program. Dr. D. O. Toft serves as Director and Dr. T. C. Spelsberg as Co- Director. The order of th projects in this renewal application is as follows: Project 1 Dr. Spelsberg Chromatin acceptor sites for progesterone Project 2 Dr. Toft Isolation and characterization of progesterone receptor Project 3 Dr. Tindall Characterization of early growth response genes in prostate cells Project 4 Dr. Roche Structure and function studies of gonadotropin receptor