MOTOR LEARNING IN PARKINSONS DISEASE

帕金森病的运动学习

• 批准号: 2891436
• 负责人: M. Felice Marina GHILARDI
• 金额: $ 10万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891436
• 关键词: Parkinson's disease; bioimaging /biomedical imaging; blood flow measurement; brain electronic stimulator; brain imaging /visualization /scanning; clinical research; computational neuroscience; functional magnetic resonance imaging; human subject; learning; neural information processing; positron emission tomography; psychosurgery

The proposed mentored research award aims to develop the applicant's basic research skills and to prepare her for independent investigations directed at exploring and dissecting the neural bases of motor and related dysfunctions in neurological disorders and normal aging using imaging techniques, psychophysical studies and brain network modeling. The primary mentor for this plan is Dr. David Eidelberg, a neurologist with vast experience in the field of PET imaging and movement disorders. Dr. Claude Ghez, a neuroscientist who has worked in the field of motor control for over 25 years will serve as co-mentor. Dr. Glyn Johnson, experienced physicist in the field of magnetic resonance, will serve as consultant to instruct the applicant in functional MRI. Drs. Jim Moeller and Eva Petkova will further the applicant's education in advanced statistics. Dr. Vijay Dhawan will be consultant for PET biophysics and quantification. Dr. Ken Perrine, neuropsychologist, will also be available as consultant. Research plan: The goal of this study is to characterize changes in neural processing underlying implicit and explicit forms of motor learning in patients with Parkinson's disease and in a control normal aging population. A new family of motor tasks developed in Dr. Ghez's lab will be used during 150-H2O positron emission tomography. A new analytical methodology based on principal component analysis will be applied on measures of regional blood flow to determine how inter- subject differences in motor learning are reflected in modulations of brain network expression. These same methods will be used to determine the neural bases of two therapeutic inventions in Parkinson's disease, ventral pallidotomy and pallidal stimulation, and to assess their effectiveness in reversing alterations in motor learning. Educational plan: The educational plan will focus on the following objectives: 1) Completion of the research plan. 2) Learning imaging techniques, including image acquisition and analysis using PET and fMRI. 3) Development of testing techniques to be used in fMRI. 4) Acquisition of skills in brain network analysis (including SSM) to be applied to both PET and NMR imaging. 5) Furthering the applicants statistical and computational skills through courses taken at Columbia University School of Public Health. 6) Developing the applicant's laboratory management, supervision, research communication and mentoring skills. 7) Receiving instruction in the responsible conduct of research.

建议的导师研究奖旨在发展申请人的 基本的研究技能，并为她的独立做好准备 旨在探索和解剖神经基础的研究 神经系统疾病和正常人的运动和相关功能障碍 老化使用成像技术，心理物理学研究和大脑 网络建模这个计划的主要指导者是大卫博士 Eidelberg是一位在PET领域拥有丰富经验的神经学家， 成像和运动障碍。神经科学家克劳德·盖兹博士 在电机控制领域工作超过25年的人将 担任共同导师。格林约翰逊博士，经验丰富的物理学家在 磁共振领域，将作为顾问，指导 功能性磁共振成像吉姆·莫勒和伊娃·佩特科娃医生 促进申请人在高级统计学方面的教育。Vijay博士 Dhawan将担任PET生物物理学和量化的顾问。博士 神经心理学家Ken Perrine也将担任顾问。 研究计划：本研究的目标是描述 运动的内隐和外显形式背后的神经加工 帕金森病患者和正常对照组的学习能力 人口老龄化在Ghez博士的研究中， 实验室将在150-H2O正电子发射断层扫描期间使用。一个新 基于主成分分析的分析方法将是 应用于区域血流的测量，以确定 运动学习的主体差异反映在 脑网络表达这些方法将用于 确定两个治疗发明的神经基础， 帕金森病，腹侧苍白球切开术和苍白球刺激，以及 以评估它们在逆转运动改变方面的有效性， 学习 教育计划：教育计划将重点关注以下内容 目标：1）完成研究计划。2)学习成像 技术，包括使用PET的图像采集和分析， 功能磁共振成像。3)开发用于功能磁共振成像的测试技术。四、 获得大脑网络分析技能（包括SSM） 适用于PET和NMR成像。5)促进申请人 通过在哥伦比亚大学学习的课程掌握统计和计算技能 大学公共卫生学院。6)开发申请人的 实验室管理、监督、研究交流和 指导技能。7)接受负责任行为的指导 的研究。