ANESTHETICS AND CARDIOPROTECTIVE SIGNAL TRANSDUCTION

描述 (改编自申请者摘要)临床导师候选人 科学家发展奖被授予加州大学医学博士学位 并在威斯康星州大学完成麻醉学实习 爱荷华州和威斯康星州医学院的研究奖学金。在.期间 团契训练应试者调查麻醉剂在 慢性仪器化犬冠状动脉血管反应性。 拟议的奖励将使候选人能够实现以下目标 目标：1)建立广泛的科学知识基础 和研究方法；2)明确心脏保护的机制 挥发性麻醉药在缺血再灌注心肌中的作用： 3)允许候选人独立策划和进行基础研究。 研究发展计划将促进应聘者的成就 通过提供进修机会实现这些目标 分子和细胞生物学及心血管生理学 多样化的学术研究环境。候选人将在她身上得到指导。 心脏病学跨学科研究小组的努力， 生理学、药理学和麻醉学。机会将是 可供候选人介绍和讨论正在进行的研究 其他年轻的研究人员在几个多产、设备齐全的实验室工作。 在这种环境下，候选人将调查 异氟醚和氟烷调节心脏保护作用的挥发性麻醉剂 信号转导。三磷酸腺苷调节钾的作用 (KATP)通道、腺苷受体和蛋白激酶C的激活 挥发性麻醉药促进顿抑心肌功能恢复的研究 和模拟缺血预适应，我们将在 装备精良的狗。将进行更多的研究以评估 这些麻醉药对全细胞KATP电流的作用 缺血和麻醉药对G蛋白影响的研究 在心肌中的表达。 该奖项将为候选人的发展奠定基础 一名独立的调查人员，结果最终将有助于 心血管疾病患者围手术期护理的改进 疾病。(摘要结束)

DESCRIPTION (Adapted from applicant's abstract) The candidate for the Mentored Clinical Scientist Development Award was awarded the MD degree from the University of Wisconsin and completed a residency in Anesthesiology at the University of Iowa and a research fellowship at the Medical College of Wisconsin. During fellowship training the candidate investigated the actions of anesthetics on coronary vascular reactivity in chronically-instrumented dogs. The proposed award will enable the candidate to accomplish the following objectives: 1) develop a broadly based foundation of scientific knowledge and research techniques; 2) define the mechanisms of cardioprotective actions of volatile anesthetics in post-ischemic, reperfused myocardium: and 3) allow the candidate to independently plan and conduct basic research. The research development plan will facilitate the candidate's accomplishment of these objectives by providing opportunities for advance education in molecular and cellular biology and cardiovascular physiology in a rich and varied academic research environment. The candidate will be directed in her efforts by an interdisciplinary group of investigators in cardiology, physiology, pharmacology and anesthesiology. Opportunities will be available for the candidate to present and discuss research in progress with other young investigators in several productive, well-equipped laboratories. Within this environment, the candidate will investigate the actions of the volatile anesthetics, isoflurane and halothane, to modulate cardioprotective signal transduction. The role of adenosine triphosphate-regulated potassium (KATP) channels, adenosine receptors and protein kinase C activation by volatile anesthetics to enhance functional recovery of stunned myocardium and to mimic ischemic preconditioning will be examined in acutely-instrumented dogs. Additional studies will be performed to evaluate the actions of these anesthetics on whole cell KATP currents and to investigate the interactions of ischemia and anesthetics on G protein expression in myocardium. This award will provide a foundation for the development of the candidate as an independent investigator, and the results will ultimately contribute to improvement in the perioperative care of patients with cardiovascular disease. (End of abstract)