SAMPLE PREPARATION MODULE FOR PLATELET TESTING ON TFT

一种采用微管流室技术的血液采集模块 将开发(TFT)平台以创建全自动样本 血小板功能检测准备及检测系统。专有的 TFT系统集生物技术、微流控技术和计算机化于一体 成像技术实现小型化。这项提案的重点是 一次性血样管组及采血装置的研制 与TFT平台配合使用的常规模块。初步结果显示 证明TFT平台可用于血小板功能检测 灵敏度高，只需少量全血。这个 研究人员将通过优化血液样本模块来进一步开发 易于使用的材料和设计，只需极少的血小板或没有血小板 激活。在样本采集和处理过程中的血小板激活 目前测试结果可变性的主要来源之一，应该是 用TFT系统消除了。调查人员认为这项研究具有 对其他体外诊断试验的潜在价值。 建议的商业应用： 为许多临床测试，特别是血小板功能测试准备样品， 是复杂的，使得这些检测无法进入护理点市场。最近的 旨在改变体内血小板功能的药物的开发导致了一种 对易于使用、准确、快速和无生物危害的血小板的需求增加 适用于所有诊断市场的功能测试。填补这一空白的是血液采样模块 本文提出，与TFT系统相结合，集成了血小板功能检测 以经济高效的方式与各种其他临床测试相结合。

A blood sampling module used with the tubule flow chamber technology (TFT) platform will be developed to create a fully automated sample preparation and testing system for platelet function testing. The proprietary TFT system incorporates biotechnology, microfluidic technology and computerized imaging technology to achieve miniaturization. This proposal focuses on the development of the disposable blood sample tubule set and the blood collection module for routine use with the TFT platform. Preliminary results have demonstrated that the TFT platform can be used for platelet function testing with high sensitivity, using only small amount of whole blood. The investigators will further develop the blood sample module by optimizing the materials and design for ease to use with minimal or no platelet activation. Platelet activation during sample collection and processing is currently one of major sources of test result variability and should be eliminated with the TFT system. The investigators feel this research has potential value for other in vitro diagnostic tests. PROPOSED COMMERCIAL APPLICATION: Sample preparation for many clinical tests, especially for platelet function testing, is complex, making these assays inaccessible to the point-of-care market. The recent development of drugs designed to alter in vivo platelet function has resulted in an increased demand for an easy to use, accurate, rapid, and biohazard-free platelet function testing for all diagnostic markets. Filling this niche, the blood sampling module proposed here, when combined with the TFT system, integrates platelet function testing with a variety of other clinical tests in a cost-effective manner.