DEVELOPMENT OF PLATELET FUNCTION TESTING ON TFT

微管流室技术(TFT)平台，用于 血液采样模块将被开发出来，以创建一个完全自动化的样本 血小板功能检测准备及检测系统。专有的 TFT系统集生物技术、微流控技术和计算机化于一体 成像技术实现小型化。这项提案的重点是 TFT常规血小板功能检测平台的研制 初步结果表明TFT平台在血小板检测中的应用 高灵敏度的功能测试，仅使用少量的整体 血。调查人员将进一步开发三大模块 TFT平台；样品包装、流量控制和成像系统。这个 将开发用于TFT平台的血小板功能分析。 目前，在样本采集和处理过程中激活血小板是 测试结果可变性的主要来源，应通过 TFT系统。这项研究被认为对其他体外实验具有潜在的价值 诊断性测试。 建议的商业应用： 目前尚无全自动化的血小板功能检测方法。最近的 一些旨在改变体内血小板功能的药物的开发取得了成果 在对易于使用、准确、快速和无生物危害的血小板的需求不断增加的情况下 大型临床实验室和医疗服务中心均可使用功能测试平台 网站。为了填补这一空白，TFT系统将血小板功能测试与各种 以具有成本效益的方式进行其他临床测试。因此，TFT的商业潜力 系统是广泛的。

The tubule flow chamber technology (TFT) platform, for use with the blood sampling module, will be developed to create a fully automated sample preparation and testing system for platelet function testing. The proprietary TFT system incorporates biotechnology, microfluidic technology and computerized imaging technology to achieve miniaturization. This proposal focuses on the development of the TFT platform for routine platelet function testing. Preliminary results have demonstrated the use of the TFT platform for platelet function testing with high sensitivity, using only small amount of whole blood. The investigators will further develop the three major modules of the TFT platform; the sample packing, flow control, and imaging systems. The platelet function assay will be developed for use with the TFT platform. Platelet activation during sample collection and processing is currently one of the major sources of test result variability and should be eliminated with the TFT system. This research is felt to have potential value for other in vitro diagnostic tests. PROPOSED COMMERCIAL APPLICATION: Currently there is not fully automated method for platelet function testing. The recent development of a number of drugs designed to alter in vivo platelet function has resulted in an increased demand for an easy to use, accurate, rapid, and biohazard-free platelet function testing platform accessible to larger clinical laboratories as well as point-of-care sites. Filling this niche, the TFT system integrates platelet function testing with a variety of other clinical tests in a cost-effective manner. Thus, the commercial potential of the TFT system is extensive.