TSH AND THYROID HORMONES IN URINE

尿液中的 TSH 和甲状腺激素

• 批准号: 6210740
• 负责人: HILTON A SALHANICK
• 金额: $ 19.42万
• 依托单位: BIODIAGNOSTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6210740
• 关键词: clinical research; diagnosis design /evaluation; endocrine disorder diagnosis; hormone metabolism; hormone regulation /control mechanism; human subject; thyroid disorder; thyroid function; thyroid hormones; thyrotropin; thyroxine; triiodothyronine; urinalysis

In the United States, more than ten million men and women are being monitored for thyroxine therapy. About 15% of women over 65 years old are at risk for sub-clinical hypothyroidism and 4.5 million pregnant women and about two million postpartum women are at increased risk of some form of thyroid dysfunction. The usual method of diagnosing and monitoring these persons is with serum thyroid stimulating hormone levels and serum levels of thyroxine. Cost-effective analyses confirm that diagnostic effectiveness proportionally as the cost of testing decreases. The objective of this project is to try to measure levels of the various thyroid hormones in urine to seek simpler, less expensive and more efficient screening and monitoring procedures. PROPOSED COMMERCIAL APPLICATIONS: A method of measuring thyroid stimulating hormone and thyroid hormones in urine could be a useful addition to current methods of evaluating thyroid function.

在美国，1000多万男性和女性正在接受甲状腺激素治疗的监测。在65岁以上的妇女中，约有15%面临亚临床甲状腺功能减退的风险，450万孕妇和约200万产后妇女患某种形式的甲状腺功能障碍的风险增加。诊断和监测这些人的通常方法是用血清促甲状腺激素水平和血清甲状腺激素水平。成本效益分析证实，随着检测成本的降低，诊断效果成比例。该项目的目标是尝试测量尿中各种甲状腺激素的水平，以寻求更简单、更便宜和更有效的筛查和监测程序。拟议的商业应用：一种测量尿中促甲状腺激素和甲状腺激素的方法可能是对目前评估甲状腺功能的方法的有益补充。