DEVELOPMENT OF A NON-INSTRUMENTED PROTHROMBIN TIME TEST

非仪器化凝血酶原时间测试的开发

• 批准号: 6317411
• 负责人: Wai Tak Law
• 金额: $ 11.22万
• 依托单位: PORTASCIENCE, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-05 至 2001-03-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6317411
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; consumable /disposable biomedical equipment; human tissue; material; prothrombin time; thromboplastin

Development of a disposable non-instrumented prothrombin time test (PF) for home use is proposed. Preliminary data using flow channels built with precision engineered fabric demonstrated the potential of the proposed test device. The end points of the flow of the blood samples stopped due to clotting were repeatable, easy to read, and there was correlation between PT observed and the bar length observed. A simple and accurate disposable device is potentially a powerful tool to help patient to monitor their PT at home weekly. We propose to further study, optimize, and develop a non-instrumented device that will he less expensive and more convenient for both the physician and patient to monitor PT values than instruments that are currently available. PROPOSED COMMERCIAL APPLICATION: There are more than 2 million patients in the U.S.A. alone that are taking oral anti-coagulation therapy, and need to monitor their PT weekly. The potential market for a use monitoring device is very large. The proposed device is expected to provide a simple, and accurate alternative to the current techniques.

本文提出了一种家庭使用的一次性非仪器化凝血酶原时间试验（PF）。 使用精密工程织物构建的流动通道的初步数据证明了所提出的测试装置的潜力。由于凝血而停止的血液样本流动的终点是可重复的，易于读取，并且观察到的PT与观察到的条长度之间存在相关性。一个简单而准确的一次性设备可能是一个强大的工具，以帮助患者监测他们的PT在家里每周。我们建议进一步研究、优化和开发一种非仪器设备，与目前可用的仪器相比，该设备更便宜，更方便医生和患者监测PT值。拟定商业应用：仅在美国就有超过200万患者正在接受口服抗凝治疗，并且需要每周监测他们的PT。使用监测设备的潜在市场非常大。所提出的设备预计将提供一个简单的，准确的替代目前的技术。