ENHANCED BIOCOMPATIBLE NON-POROUS BLOOD OXYGENATORS

基于膜的血液氧合器成功地用于心肺旁路（CPB）手术。许多项目正在评估用于人工肺和急性呼吸窘迫综合征（ARDS）的长期膜式血液氧合器。对于短期使用（CPB）和长期使用（ARDS），需要增强的血液相容性表面。目前用于增强血液相容性的两种涂层系统的实例是Avecor的Trillium和Medtronic的Carmeda。虽然这两种系统在增强血液相容性方面都取得了一些成功，但成功是有限的。此外，它们倾向于减少气体（氧气）流量，最重要的是它们倾向于润湿。紧凑膜系统（CMS）提出开发具有优异的（1）抗润湿性、（2）气体通量和（3）血液相容性的新型无孔表面。增强的血液相容性将基于已知的血液生物相容性系统。在第一阶段，CMS将开发这些新结构，并在体外环境中展示增强的性能。拟议的商业应用：该项目的成功完成将大大改善每年50万例CPB手术的治疗。它也将成为提高与ARDS相关的长期治疗潜力的基石。

Membrane based blood oxygenators are successfully used for cardiopulmonary by-pass (CPB) surgery. A number of programs are evaluating long-term membrane based blood oxygenators for artificial lungs and acute respiratory distress syndrome (ARDS). For both short- term use (CPB) and long-term use (ARDS), there is a need for enhanced blood compatible surfaces. Examples of two coating systems that are presently used to enhance blood compatibility are Avecor's Trillium and Medtronic's Carmeda. While both of these systems have some success in enhancing blood compatibility, the success is limited. Also, they tend to reduce gas (oxygen) flux and most importantly they are prone to wetting out. Compact Membrane Systems (CMS) proposes the development of a novel non-porous surface having excellent (1) wet-out resistance, (2) gas flux, and (3) blood compatibility. Enhanced blood compatibility will be based on known blood biocompatible systems. In Phase I, CMS will develop these novel structures and demonstrate enhanced performance in an in-vitro environment. PROPOSED COMMERCIAL APPLICATIONS: Successful completion of this project will significantly improve the treatment of the 500,000 CPB surgeries per year. It will also be a cornerstone in improving the potential of long-term therapy associated with ARDS.