CHEMILUMINESCENCE BIOCHIP FOR IMMUNOASSAY

目前临床上使用的自动化单机或集成模块化系统 实验室只有在收集了大量样本后才能运作，这通常需要几天的时间 让患者知道检测结果。这些系统要么是作为工作建造的- 工作台或工作台，这两种设备都不适合近距离就诊地点或 护理点测试。麦克斯韦传感器公司计划开发一种紧凑型、 全自动照料点化学发光测定仪 自含式小型化化学发光芯片(CLCHIP)和 微机械执行器，用于快速和灵敏的临床诊断。这完全是 自动化系统有望实现大气压灵敏度。在第一阶段期间 项目，他们将设计和制造微芯片，建造 微执行器，通过临床测试对系统进行表征和评估 相关分析：促黄体生成素(LH)、甲状旁腺激素(PTH)和 肌钙蛋白(CTnI)。 建议的商业应用： 提供简单、快速结果的医疗点测试产品正在获得认可 在医学界。提议的技术并不局限于 发光法，但可扩展为酶联免疫吸附试验和荧光免疫分析。 它还可以应用于各种特异性和常规性的临床诊断。

Current automated stand-alone or integrated modular systems used in clinical laboratories only operate after a large collection of samples, it often takes days for patients to know the test results. These systems are built either as work- stations or bench-tops, neither of which are suitable for near-patient site or point-of-care testing. Maxwell Sensors Inc. proposes to develop a compact, automated point-of-care chemiluminescent luminometer by combining a self-contained miniaturized chemiluminescence chip (CLCHIP) and a micromechanical actuator for rapid and sensitive clinical diagnostics. This fully automated system is expected to achieve attomolar sensitivity. During Phase I project, they will design and fabricate the microchip, construct the micro-actuator, characterize and evaluate the system by testing the clinically relevant analytes: luteinizing hormone (LH), parathyroid hormone (PTH), and troponin (cTnI). PROPOSED COMMERCIAL APPLICATION: Point-of-care test products offering simple and rapid results are gaining acceptance among the medical community. The proposed technology is not limited to the luminesence assay, but can be expanded to ELISA and fluorescence immunoassay. It can also be applied to various specific and routine clinical diagnosis.