X-RAY DETECTORS FOR SYNCHROTRON-BASED STRUCTURAL BIOLOGY

描述（来自申请人摘要的逐字描述）。的发展 集成电路x射线像素阵列探测器（PAD）被提出来增强 同步辐射源的大分子晶体学数据收集。数据 收集时间可以减少40倍，数据质量得到改善。 我们的最终目标是设计和制造一个具有2000 x 2000像素的PAD。 150微米x 150微米，可以： 1)在18秒内收集一组单色数据（90度旋转），使用 标准方法（每帧0.5度，每帧曝光100 ms） 框架）。 2)在90秒内采集一组精细切片数据，旋转0.05 每帧50度，每帧50毫秒的曝光。 3)收集多达8个连续帧用于时间分辨蛋白质晶体学 使用劳厄衍射。 我们在第一阶段的目标是测试16 x 16像素PAD的原型， （APAD），另一个数字（DPAD），以选择最佳的方法来建立 第二阶段的大型商业定位探测器。这两种类型都将减少 读出过程的时间损失几乎为零。这些16 x 16像素 原型将按照耐辐射布局重新设计并重新测试。一 然后将在APAD和DPAD或混合方法之间做出决定。然后 将制造中等规模（50 × 50或100 × 100像素）的模块化探测器。 在第二阶段，我们将完成模块化媒体的设计 缩放阵列并组装大型2000 x 2000像素阵列检测器， 科学测试。在第三阶段，我们将建立一个完全商业化的版本， 这将满足所有的验收，UL，和CE测试。第三阶段还将 包括成本和销售研究。 拟议商业应用：不可用

DESCRIPTION (Verbatim from the Applicant's Abstract). The development of Integrated-circuit x-ray Pixel Array Detectors (PAD) is proposed to enhance macromolecular crystallographic data collection at synchrotron sources. Data collection time can be reduced by a factor of 40 with improved data quality. Our ultimate aim is to design and fabricate a PAD having 2000 x 2000 pixels of 150 micrometers x 150 micrometers which can: 1) Collect a set of monochromatic data (90 degree rotation) in 18 seconds using a standard method (0.5 degrees per frame, with an exposure of 100 ms per frame). 2) Collect a set of fine slice data in 90 seconds with a rotation of 0.05 degrees per frame and with an exposure of 50 ms per frame. 3) Collect up to 8 successive frames for time resolved protein crystallography using Laue diffraction. Our aim in Phase I is to test prototypes of 16 x 16 pixel PAD, one analog (APAD), the other digital (DPAD), in order to select the best approach to build a large commercial positioned detector in Phase II. Both types will reduce the time loss for the readout process to almost nothing. These 16 x 16 pixel prototypes will be redesigned in a radiation tolerant layout and re-tested. A decision will then be made between APAD and DPAD or mixed approach. Then a medium scale (50 x 50 or 100 x 100 pixel) modular detector will be fabricated. In Phase II we will put the finishing touches to the design of a modular medium scale array and assemble a large 2000 x 2000 pixel array detector for scientific testing. In Phase III we will build a totally commercial version that would meet all the acceptance, UL, and CE testings. Phase III will also include cost and marketing studies. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE