X-RAY DETECTORS FOR SYNCHROTRON-BASED STRUCTURAL BIOLOGY

描述(逐字摘自申请人的摘要)。的发展。 提出了集成电路X射线像素阵列探测器(PAD)来增强 在同步加速器源上收集大分子晶体数据。数据 采集时间可缩短到原来的1/40，数据质量也随之提高。 我们的最终目标是设计和制造一个具有2000 x 2000像素的 150微米x 150微米，可以： 1)18秒内采集一组单色数据(90度旋转)，使用 标准方法(每帧0.5度，每帧曝光100毫秒 帧)。 2)旋转0.05次，在90秒内采集一组细切片数据 每帧的曝光时间为50毫秒。 3)收集多达8帧连续的时间分辨蛋白质结晶学 使用劳厄衍射。 我们在第一阶段的目标是测试16x16像素Pad的原型，一个模拟 (APAD)，另一个数字(DPAD)，以便选择最佳的构建方法 一个大型商用探测器在第二阶段。这两种类型都将减少 读出过程的时间损失几乎为零。这些16x16像素 原型将以耐辐射布局重新设计并重新测试。一个 然后将在APAD和DPAD或混合方法之间做出决定。然后是一个 将制造中等规模(50x50或100x100像素)的模块化探测器。 在第二阶段，我们将对模块化介质的设计进行最后的润色 缩放阵列并组装大型2000 x 2000像素阵列探测器 科学测试。在第三阶段，我们将打造一个完全商业化的版本 这将满足所有的验收、UL和CE测试。第三阶段亦会 包括成本和营销研究。 建议的商业应用：不可用

DESCRIPTION (Verbatim from the Applicant's Abstract). The development of Integrated-circuit x-ray Pixel Array Detectors (PAD) is proposed to enhance macromolecular crystallographic data collection at synchrotron sources. Data collection time can be reduced by a factor of 40 with improved data quality. Our ultimate aim is to design and fabricate a PAD having 2000 x 2000 pixels of 150 micrometers x 150 micrometers which can: 1) Collect a set of monochromatic data (90 degree rotation) in 18 seconds using a standard method (0.5 degrees per frame, with an exposure of 100 ms per frame). 2) Collect a set of fine slice data in 90 seconds with a rotation of 0.05 degrees per frame and with an exposure of 50 ms per frame. 3) Collect up to 8 successive frames for time resolved protein crystallography using Laue diffraction. Our aim in Phase I is to test prototypes of 16 x 16 pixel PAD, one analog (APAD), the other digital (DPAD), in order to select the best approach to build a large commercial positioned detector in Phase II. Both types will reduce the time loss for the readout process to almost nothing. These 16 x 16 pixel prototypes will be redesigned in a radiation tolerant layout and re-tested. A decision will then be made between APAD and DPAD or mixed approach. Then a medium scale (50 x 50 or 100 x 100 pixel) modular detector will be fabricated. In Phase II we will put the finishing touches to the design of a modular medium scale array and assemble a large 2000 x 2000 pixel array detector for scientific testing. In Phase III we will build a totally commercial version that would meet all the acceptance, UL, and CE testings. Phase III will also include cost and marketing studies. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE