Evaluation of the role of ARAP1 in platelet function and thrombosis

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Platelets are small cells in the blood that are important to stop a bleeding but can also cause a stroke or heart attack when they clump together in a blood vessel in the brain or heart. We recently found that platelets that like to clump together more than other platelets have increased activity of a protein called PI3 kinase. The PI3kinase protein can communicate with other proteins and one of these is a protein called ARAP1. The aim of this study is to investigate whether the ARAP1 protein is responsible for making platelets hyperactive, which may thereby contribute to strokes and heart attacks.