Evaluation of the role of ARAP1 in platelet function and thrombosis

血小板是血液中的小细胞，对止血很重要，但当它们聚集在大脑或心脏的血管中时，也可能导致中风或心脏病发作。我们最近发现，与其他血小板相比，更喜欢聚集在一起的血小板会增加一种名为PI3激酶的蛋白质的活性。PI3蛋白可以与其他蛋白质交流，其中一种是名为ARAP1的蛋白质。这项研究的目的是调查ARAP1蛋白是否导致血小板过度活跃，从而可能导致中风和心脏病发作。

Platelets are small cells in the blood that are important to stop a bleeding but can also cause a stroke or heart attack when they clump together in a blood vessel in the brain or heart. We recently found that platelets that like to clump together more than other platelets have increased activity of a protein called PI3 kinase. The PI3kinase protein can communicate with other proteins and one of these is a protein called ARAP1. The aim of this study is to investigate whether the ARAP1 protein is responsible for making platelets hyperactive, which may thereby contribute to strokes and heart attacks.