NOVEL APPROACH TO DELIVERING EXCIMER UV ENERGY FOR PRK

为 PRK 提供准分子紫外线能量的新方法

• 批准号: 6150972
• 负责人: ROY E WILLIAMS
• 金额: $ 31.06万
• 依托单位: FEO MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6150972
• 关键词: argon; bioengineering /biomedical engineering; biomedical device power system; biomedical equipment development; eye laser surgery; fluorine; lasers; microsurgery; ultraviolet radiation; visual tracking

DESCRIPTION: (Adapted From The Investigator's Abstract): Refractive keratotomy, the dominant method for surgical correction of refractive error, has one main weakness - the inability to predict accurately the outcome of surgery for an individual patient. Excimer ultraviolet (UV) lasers offer a potential solution to this problem if they are coupled to an effective laser delivery system. Photorefractive Keratectomy (PRK), or laser-based corneal surgery, can be implemented through many types of laser delivery configurations. The two most successful ones are the expanding iris technique, which offers a simple implementation but is limited to treating myopia, and the scanning spot technique which offers the greatest treatment flexibility but with extended treatment times and complicated delivery hardware. FEO Medical proposes to deliver complex correction patterns to the cornea in substantially reduced treatment times using a novel technique based on a digital, micromachined device, consisting of a 640x480 array of individually- controlled micromirrors, coupled to a digital corneal topography system. During Phase I, computer-generated test patterns will be etched onto various UV-sensitive test materials. The resulting etch patterns will be compared to the known patterns to measure the success of the project and establish a basis for the Phase II effort which will involve animal and human studies.

描述：（改编自研究者的摘要）：屈光 角膜切开术是矫正屈光手术的主要方法 错误，有一个主要弱点 - 无法准确预测 个别患者的手术结果。 准分子紫外线 (UV) 如果激光器耦合的话，可以为这个问题提供一个潜在的解决方案 到有效的激光传输系统。 屈光性角膜切除术（PRK）或基于激光的角膜手术可以 可以通过多种类型的激光传输配置来实现。 这 两个最成功的技术是扩张虹膜技术，它提供了 一个简单的实现，但仅限于治疗近视，并且 扫描点技术提供最大的治疗灵活性 但治疗时间延长且输送硬件复杂。 FEO Medical 提议为角膜提供复杂的矫正模式 使用基于新技术的新技术大大减少了治疗时间 在数字微机械设备上，由 640x480 阵列组成 单独控制的微镜，与数字角膜耦合 地形系统。 在第一阶段，计算机生成的测试图案将被蚀刻到 各种紫外线敏感测试材料。 由此产生的蚀刻图案将 与已知模式进行比较以衡量项目的成功 并为涉及动物的第二阶段工作奠定基础 和人类研究。