MELATONIN EFFECTS ON DAMAGED DOPAMINE NEURONS

描述多巴胺（DA）神经元特别容易受到损伤， 死亡，以及它们在人类中的损失与疾病有关， 帕金森病（PD）。 有大量证据表明， PD中DA神经元的破坏涉及游离 根的 抗氧化激素，褪黑激素，是最有效的 氧自由基的内源性清除剂，但其拯救、预防或 对DA神经元的修复损伤尚未直接研究。 这项建议 试图在几个实验室模型中测试褪黑激素对DA神经元的影响 与氧化应激相关，包括生长因子剥夺或 MPP+或6-OHDA的神经毒性损伤。 初步研究显示， 褪黑激素具有拯救发育和神经毒素损伤的显著能力 DA神经元在培养和体内的细胞死亡，并进一步 促进DA纤维的生长和再生。 这个项目的最终目标 研究是为了更全面地了解褪黑激素的作用 可能在增加受损DA系统中神经元的存活方面发挥作用 为开发PD等疾病的治疗方法奠定基础 地方检察官系统受损

DESCRIPTION Dopamine (DA) neurons are uniquely vulnerable to damage and cell death, and their loss in humans is associated with diseases including Parkinson's disease (PD). There is a large body of evidence suggesting that the destruction of DA neurons in PD involves the accumulation of free radicals. The antioxidant hormone, melatonin, is one of the most potent endogenous scavengers of oxyradicals yet its ability to rescue, prevent or repair damage to DA neurons has not been directly studied. This proposal seeks to test melatonin's effects on DA neurons in several laboratory models associated with oxidative stress, including growth factor deprivation or neurotoxic injury from MPP+ or 6-OHDA. Preliminary studies reveal a remarkable ability of melatonin to rescue developing and neurotoxin- damaged DA neurons from impending cell death in culture and in vivo and to further promote the growth and regeneration of DA fibers. The ultimate goal of this research is to provide a fuller understanding of the role that melatonin might play in increasing the survival of neurons in the injured DA system and lay a foundation for development of treatments for PD and other diseases with compromised DA systems.