IMPACT OF MICRONUTRIENTS ON PROGRESSION OF SIV

微量营养素对 SIV 进展的影响

• 批准号: 2798812
• 负责人: SHERWOOD GORBACH
• 金额: $ 37.39万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2798812
• 关键词: AIDS therapy; CD4 molecule; Macaca mulatta; body weight; cachexia; dietary supplements; malnutrition; nonhuman therapy evaluation; opportunistic infections; pathologic process; selenium; simian immunodeficiency virus; vitamin B12; vitamin B12 deficiency; weight loss

DESCRIPTION : (duplicated from the abstract provided) Studies in patients with HIV infection have revealed that serum micronutrient levels are often below normal levels particularly for vitamins A, B12, E and for selenium. Some studies have correlated low micronutrient levels with more rapid progression of HIV infection. Intervention trials with micronutrients are extremely difficult to carry out in persons with HIV for the following reasons : a large percentage of HIV/AIDS patients are already taking nutritional supplements in an uncontrolled manner, some in large doses; intake of micronutrients in food varies greatly among persons with HIV infection; there are complex ethical issues surrounding a placebo controlled trial of micronutrients in the HIV/AIDS population; it would be difficult to maintain a micronutrient intervention study during the years of progression of HIV infection; and current and rapidly changing anti-retroviral therapies will alter the natural history of HIV, making it complex to separate out the effects of micronutrient intervention. Yet, micronutrient supplements might play an important role in improving overall nutritional status and slowing the progression of HIV infection. The Simian immunodeficiency virus (SIV) produces an infection in juvenile rhesus monkeys that is remarkably similar to that caused by HIV in humans including, as we have found recently, serum micronutrient deficiencies despite an apparently adequate intake. SIV also causes a wasting condition similar to that seen in young persons with HIV. Because of the rapid progression in SIV, and the clear end points of nutritional parameters, biological markers, and survival, as well as a controlled dietary intake, the SIV-infected rhesus monkey is an ideal model to examine the potential benefit of micronutrient supplementation. To this end we plan to: 1) document the course of micronutrient deficiency and weight loss in SIV-infected juvenile rhesus macaques compared to age matched uninfected control animals; and 2) conduct 3 interventions with micronutrients in SIV infected macaques, including a high supplementation with vitamins and trace minerals; single supplementation with vitamin B12 intramuscularly; and a single supplementation selenium. End points include time of death; body weight and lean body mass; serum micronutrients; viral load; CD4 cell count; and development of opportunistic infections. These studies will allow the evaluation of the efficacy of micronutrient supplements in the monkey SIV model without the confounding factors involved in a study in human HIV infection. In addition, the natural history of nutritional deficits and wasting would be defined in this model, which would provide a basis for further studies on nutritional interventions.

描述：（复制自提供的摘要） 对HIV感染患者的研究表明， 微量营养素水平通常低于正常水平，特别是 维生素A，B12，E和硒。一些研究表明， 微量营养素水平与艾滋病毒感染的更快进展有关。 微量营养素的干预试验极难携带 由于以下原因，艾滋病毒感染者的患病率很高：很大比例 的艾滋病毒/艾滋病患者已经在服用营养补充剂， 不受控制的方式，一些在大剂量;摄入微量营养素， 艾滋病毒感染者的食物差异很大;有复杂的 围绕微量营养素安慰剂对照试验的伦理问题 在艾滋病毒/艾滋病人群中， 在艾滋病毒进展期间进行的微量营养素干预研究 以及当前和迅速变化的抗逆转录病毒疗法 将改变HIV的自然历史，使其分离变得复杂， 微量营养素干预的效果。然而，微量营养素 补充剂可能在改善整体 营养状况和减缓艾滋病毒感染的进展。的 猴免疫缺陷病毒（SIV）在青少年中引起感染 恒河猴，这是非常相似的，由艾滋病毒引起的， 包括我们最近发现的血清微量营养素 尽管有明显的不足。SIV也会导致 与感染艾滋病毒的年轻人类似的消瘦状况。 由于SIV的快速进展，以及明确的终点， 营养参数、生物标志物和存活率，以及 控制饮食摄入，SIV感染的恒河猴是理想的 这是一个研究微量营养素补充的潜在益处的模式。 为此，我们计划：1）记录微量营养素的过程 SIV感染幼年恒河猴的缺乏和体重减轻 与年龄匹配的未感染对照动物相比;和2）进行3 对SIV感染猕猴进行微量营养素干预，包括 维生素和微量矿物质的高补充;单一 肌肉内补充维生素B12;以及 补充硒。终点包括死亡时间、体重 和瘦体重;血清微量营养素;病毒载量; CD 4细胞计数; 和机会性感染的发展。 这些研究将有助于评估微量营养素的功效 在没有混杂因素的猴SIV模型中， 参与了一项人类艾滋病感染的研究。此外，自然 营养缺乏和浪费的历史将在此定义 模型，这将为进一步研究营养 干预措施。