HERITABILITY OF AN ANATOMICAL RISK FACTOR FOR DYSLEXIA

诵读困难是一种影响很大一部分儿童的阅读障碍。 解释阅读障碍的努力已经确定了阅读障碍的神经和染色体风险因素以及与阅读障碍相关的缺陷。 与阅读障碍有关的染色体标记包括与各种发育异常相关的区域。与阅读障碍相关的神经风险因素，海氏回重复，可能是被鉴定为阅读障碍染色体标记的区域内基因的表型表达的一个方面。 本研究的一个长期目标是对Heschl氏回重复进行连锁分析。 然而，必须首先建立一个谱系Heschl的脑回重复，以建立适当的连锁分析方法。 这项建议的目的是收集家系Heschl的脑回重复，然后确定染色体标记的重复。 在更广泛的层面上，这一建议将联合收割机两个领域的生物研究，旨在发展的机制，产生阅读障碍的理解。

Dyslexia is a form of reading disability that affects a significant proportion of children. Efforts to explain dyslexia have identified neural and chromosomal risk factors for dyslexia and the deficits related to dyslexia. The chromosomal markers implicated in dyslexia include regions related to a variety of developmental abnormalities. A neural risk factor related to dyslexia, Heschl's gyrus duplication, may be one aspect of the phenotypic expression of genes within the regions identified as chromosomal markers for dyslexia. A long term goal of this research will be to perform linkage analysis for Heschl's gyrus duplication. However, a pedigree for Heschl's gyrus duplication must first be developed in order to establish the proper linkage analysis approach. This proposal is designed to collect pedigrees for a Heschl's gyrus duplication and then identify chromosomal markers for the duplication. On a broader level, this proposal will combine two areas of biological research directed towards developing an understanding of the mechanisms that produce dyslexia.