STRUCTURAL INVESTIGATIONS OF THE ASPARTATE CHEMORECEPTOR

该项目包括一个系统的方法来调查 焦油化学感受器的结构信息。 主要目标是 阐明跨膜信号的基本机制 转导 天冬氨酸受体的独特之处在于， 这将使我们的问题得到解决。 x射线 晶体学以及电子显微镜将被用来解决 这种受体的结构，有和没有结合天冬氨酸，在 原子分辨率 这项研究的信息可以应用于其他 转导受体信号转导是一种现象， 所有细胞类型。 细菌趋化性与哺乳动物信号 两者都涉及跨膜信号转导。 突变 哺乳动物信号转导蛋白的形式通常是致癌的。 因此，更深入地了解跨膜的机制， 信号将导致更好地理解导致 癌

This project consists of a systematic approach to investigate the structural information of the Tar chemoreceptor. The primary goal is elucidation of the fundamental mechanism of transmembrane signal transduction. The aspartate receptor is unique in that it has been well characterized which will allow our question to be approached. X-ray crystallography as well as electron microscopy will be used to resolve the structures of this receptor, with and without bound aspartate, at atomic resolution. Information from this study can be applied to other transduction receptors. Signal transduction is a phenomenon that occurs in all cell types. Bacterial chemotaxis and mammalian signal transduction both involve transmembrane signal transduction. Mutated forms of mammalian signal transduction proteins are often oncogenic. Therefore, a deeper understanding of the mechanisms of transmembrane signaling will lead to a better understanding of the events that cause cancer.