MATERNAL DEPRIVATION EFFECTS ON HIPPOCAMPAL DEVELOPMENT

描述(申请者摘要)：新生儿母体贫困 老鼠会导致类似抑郁的症状，包括行为和 神经内分泌对心理应激源的高反应。这 建议询问解剖结构中的短暂和/或长期变化 和/或海马体功能是新生儿的结果 母性剥夺。许多研究都将新生儿和 成人暴露于糖皮质激素水平升高和/或应激 海马区功能障碍，包括神经元形态和 数字和认知功能。新生儿母亲的剥夺一直是 证实可以增强脑下垂体-肾上腺的反应性 应激源，可能部分是由于表达减少和 海马区糖皮质激素受体的结合，这是一个靶点 糖皮质激素对应激反应的负反馈。 糖皮质激素对齿状回神经发生和细胞凋亡的调节作用 成年大鼠和新生大鼠的海马回。这项研究要求 无论母体分离是否导致糖皮质激素水平升高 改变颗粒神经元的数量、发生、凋亡、形态和空间 学习。

DESCRIPTION (applicant's abstract): Neonatal maternal deprivation in the rat leads to depressive-like symptoms, including behavioral and neuroendocrine hyper-responsiveness to psychological stressors. This proposal asks whether transient and/or long-term changes in the anatomy and/or function of the hippocampus occur as a result of neonatal maternal deprivation. Numerous studies have linked both neonatal and adult exposure to elevated levels of glucocorticoids and/or stress with hippocampal dysfunction, including changes in neuronal morphology and number and cognitive function. Neonatal maternal deprivation has been demonstrated to accentuate the pituitary-adrenal responsiveness to stressors which may, in part, be the result of decreased expression and binding of glucocorticoid receptors in the hippocampus, a target for negative feedback by glucocorticoids on the stress response. Glucocorticoids regulate both neurogenesis and apoptosis in the dentate gyrus of the hippocampus of adult and neonatal rats. This study asks whether elevated levels of glucocorticoids due to maternal separation alter granule neuron number, genesis, apoptosis, morphology and spatial learning.