Maternal Depression, Child Temperament and Cortisol

产妇抑郁、儿童气质和皮质醇

• 批准号: 6738894
• 负责人: REBECCA L HUOT
• 金额: $ 4.7万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-17 至 2006-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6738894
• 关键词: behavioral /social science research tag; child behavior disorders; child mental disorders; child psychology; clinical research; cortisol; depression; disease /disorder proneness /risk; hormone regulation /control mechanism; human subject; longitudinal human study; maternal behavior; mother child interaction; postdoctoral investigator; psychophysiology

DESCRIPTION (provided by applicant): Offspring of depressed mothers are at increased risk for developing behavior and psychological disorders later in life. Although there is certainly a genetic component for this increased vulnerability, it is also likely that the early environment of the infant and child plays a role in determining which individuals will develop disorders versus those that will not. The experiments proposed here were designed to measure changes in infancy through early childhood in offspring of mothers depressed during the prepartum and/or postpartum periods. In addition to assessing changes in child behavior, potential mediators of maternal depression on child development will be examined. The studies proposed are unique in that they are part of a larger study and the subject base is already very well characterized for both prepartum and postpartum depression (prospectively) such that the impact of lifetime history, prepartum and postpartum depression can be disentangled. Measuring early effects of maternal depression on offspring may shed some light on individual differences that may predict later impairment. In addition, since some data has already been collected on this population, it will be possible to look at some longitudinal changes in infants and children of depressed mothers.

描述（由申请人提供）：抑郁症母亲的后代在以后的生活中出现行为和心理障碍的风险增加。虽然这种增加的脆弱性肯定有遗传因素，但婴儿和儿童的早期环境也可能在决定哪些人会患上疾病而哪些人不会方面发挥作用。这里提出的实验旨在测量母亲在准备和/或产后抑郁期间从婴儿期到幼儿期的变化。除了评估儿童行为的变化外，还将研究母亲抑郁对儿童发展的潜在中介。提出的研究是独特的，因为它们是一个更大的研究的一部分，并且受试者基础已经很好地描述了孕前和产后抑郁症（前瞻性的），因此可以解开一生历史，孕前和产后抑郁症的影响。测量母亲抑郁对后代的早期影响可能有助于揭示个体差异，从而预测日后的损害。此外，由于已经收集了这一人群的一些数据，因此有可能观察抑郁症母亲的婴儿和孩子的一些纵向变化。