CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY

该申请是为了响应面向患者研究的中期职业研究者奖（PA-98-053），该奖项旨在支持年轻、活跃和成功的临床研究者克服面向患者研究的一些主要障碍：时间、资源和指导。姜世元博士就是这样一位经过多年专业训练并致力于指导下一代临床研究者的临床研究者。该计划的目标是进一步建立候选人独立的以患者为导向的临床研究计划，特别是在临床转化研究方面，并为他提供必要的时间和资源来指导实习生进行皮肤临床研究。该项目的活动领域是Kang博士的研究计划，重点是在纤维化皮肤病中使用紫外线(UV)-A1辐射进行治疗，在体内与人体皮肤光老化相关的紫外线信号中抗氧化剂的作用，白介素-10在牛皮癣中的作用，以及他指导初级临床研究人员的计划。除了在合理的研究设计、执行和分析方面更传统的培训途径之外，这三个项目还为临床研究人员提供了一个新的培训途径，使他们能够使用可重复观察和可靠记录与人类疾病有关的分子现象所需的工具。该候选人具有指导博士前和博士后学员的良好记录。康博士的研究项目将为他继续培训初级临床调查员提供背景。他的研究和指导项目将得到密歇根大学优秀临床研究和培训项目的支持。其中包括最近授予的机构课程，向年轻的实习生和初级教师（K-30）教授临床研究的基本知识，一个资金充足的普通临床研究中心，临床调查和治疗中心，临床研究设计和统计分析教育计划，以及公共卫生学院。总之，候选人在以患者为导向的研究方面的专业知识和成就，他指导初级临床研究者的能力和承诺，以及密歇根大学的研究和培训优势，共同为实现本提案的具体目标提供了理想的环境。

This application is in response to the Mid-career Investigator Award in Patient-Oriented Research (PA-98-053) which was created to support young, active and successful clinical investigators to overcome some of the major barriers to patient-oriented research: time, resource and mentoring. Dr. Sewon Kang represents such a clinical researcher with years of specialty training and commitment to mentoring the next generation of clinical investigators. The objectives of this program are to further establish the candidate's independent patient-oriented clinical research program, especially in clinical translational research, and to provide him the time and resources necessary to mentor trainees pursuing clinical investigations in skin. The areas of activity of this project are Dr. Kang's research plan focused on therapeutic use of ultraviolet (UV)-A1 radiation in fibrosing skin diseases, effects of antioxidants in UV-signaling relevant to photoaging in human skin in vivo, and interleukin-10 in psoriasis, along with his plans for mentoring beginning clinical investigators. The three projects allow, in addition to the more traditional avenue of training in sound study design, execution, and analysis, opportunities for a novel avenue for training of clinical investigators to use tools required for reproducible observation and reliable documentation of molecular phenomenon relevant to human disease. The candidate has an established record of providing mentorship to pre- and post-doctoral trainees. Dr. Kang's research program will provide the context for him to continue to train beginning clinical investigators. His research and mentoring programs will be supported by the outstanding clinical research and training programs of the University of Michigan. These include the recently awarded institutional curriculum to teach the essentials of clinical research to young trainees and junior faculty (K-30), a well- funded General Clinical Research Center, the Center for Clinical Investigation and Therapeutics, educational program in Clinical Research Design and Statistical Analysis, and the School of Public Health. In summary, the candidate's expertise and accomplishments in patient-oriented research, his ability and commitment to mentor beginning clinical investigators, and the research and training strengths of the University of Michigan combine to provide an ideal context to accomplish the specific aims of this proposal.