CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY

该申请是对以患者为导向的研究（PA-98-053）职业生涯中期研究者奖的回应，该奖项旨在支持年轻，积极和成功的临床研究者克服以患者为导向的研究的一些主要障碍：时间，资源和指导。 Sewon Kang博士代表了这样一位临床研究者，他接受了多年的专业培训，并致力于指导下一代临床研究者。 该计划的目标是进一步建立候选人的独立的以患者为导向的临床研究计划，特别是在临床转化研究，并为他提供必要的时间和资源，指导学员进行皮肤临床研究。 该项目的活动领域是Kang博士的研究计划，重点是紫外线（UV）-A1辐射在纤维化皮肤疾病中的治疗应用，抗氧化剂在体内与人体皮肤光老化相关的UV信号传导中的作用，以及银屑病中的白细胞介素-10，沿着他指导开始临床研究者的计划。 这三个项目允许，除了在合理的研究设计，执行和分析，培训临床研究人员使用可重复的观察和可靠的文件与人类疾病相关的分子现象所需的工具的新途径的机会更传统的途径。 候选人有一个既定的记录，提供导师的前和博士后学员。 Kang博士的研究计划将为他继续培训初级临床研究人员提供背景。他的研究和指导计划将得到密歇根大学杰出的临床研究和培训计划的支持。 这些包括最近授予的机构课程，向年轻学员和初级教师（K-30）教授临床研究的基本知识，一个资金充足的综合临床研究中心，临床研究和治疗中心，临床研究设计和统计分析教育计划，以及公共卫生学院。 总之，候选人在以患者为导向的研究方面的专业知识和成就，他指导开始临床研究者的能力和承诺，以及密歇根大学的研究和培训优势结合联合收割机，为实现本提案的具体目标提供了理想的背景。

This application is in response to the Mid-career Investigator Award in Patient-Oriented Research (PA-98-053) which was created to support young, active and successful clinical investigators to overcome some of the major barriers to patient-oriented research: time, resource and mentoring. Dr. Sewon Kang represents such a clinical researcher with years of specialty training and commitment to mentoring the next generation of clinical investigators. The objectives of this program are to further establish the candidate's independent patient-oriented clinical research program, especially in clinical translational research, and to provide him the time and resources necessary to mentor trainees pursuing clinical investigations in skin. The areas of activity of this project are Dr. Kang's research plan focused on therapeutic use of ultraviolet (UV)-A1 radiation in fibrosing skin diseases, effects of antioxidants in UV-signaling relevant to photoaging in human skin in vivo, and interleukin-10 in psoriasis, along with his plans for mentoring beginning clinical investigators. The three projects allow, in addition to the more traditional avenue of training in sound study design, execution, and analysis, opportunities for a novel avenue for training of clinical investigators to use tools required for reproducible observation and reliable documentation of molecular phenomenon relevant to human disease. The candidate has an established record of providing mentorship to pre- and post-doctoral trainees. Dr. Kang's research program will provide the context for him to continue to train beginning clinical investigators. His research and mentoring programs will be supported by the outstanding clinical research and training programs of the University of Michigan. These include the recently awarded institutional curriculum to teach the essentials of clinical research to young trainees and junior faculty (K-30), a well- funded General Clinical Research Center, the Center for Clinical Investigation and Therapeutics, educational program in Clinical Research Design and Statistical Analysis, and the School of Public Health. In summary, the candidate's expertise and accomplishments in patient-oriented research, his ability and commitment to mentor beginning clinical investigators, and the research and training strengths of the University of Michigan combine to provide an ideal context to accomplish the specific aims of this proposal.