VALIDATION OF FAMILY HISTORY OF CANCER QUESTIONNAIRE

癌症家族史问卷的验证

• 批准号: 6153558
• 负责人: MARY M MASTERS
• 金额: $ 51.45万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6153558
• 关键词: Medicare /Medicaid; breast neoplasms; cancer registry /resource; cancer risk; case history; clinical research; colorectal neoplasms; data collection methodology /evaluation; family genetics; genetic susceptibility; human data; lung neoplasms; neoplasm /cancer epidemiology; neoplasm /cancer genetics; ovary neoplasms; prostate neoplasms; questionnaires

This methodologic study will provide estimates of the accuracy of family history of cancer reports in a general population setting, which will help to evaluate the feasibility of future surveillance studies of genetic risk factors for cancer. A family history of cancer questionnaire will be developed and administered to a probability sample of approximately 1600 residents in the state of Connecticut. The questionnaire will ascertain the occurrence of cancer in the respondents' first and second degree relatives. Positive and negative reports of major cancers, including breast, prostate, lung, colorectal, and ovarian cancers, will be validated by searching state tumor registry records and other data sources (i.e., Medicare records, National Death Index files or death certificates, and physician reports)in order to determine the sensitivity and specificity of family history reports. Some additional epidemiologic and psychosocial variables will be collected to examine possible predictors of reporting accuracy and completeness.

这项方法学研究将估计一般人群中癌症报告家族史的准确性，这将有助于评估对癌症遗传危险因素的未来监视研究的可行性。将开发和管理癌症问卷的家族史，并向康涅狄格州约1600名居民的概率样本进行管理。问卷将确定受访者的一级和二级亲戚的癌症发生。主要癌症（包括乳腺癌，前列腺，肺，结直肠和卵巢癌）的正面和负面报道将通过搜索状态肿瘤注册表记录和其他数据源（即Medicare记录，国家死亡指数文件或死亡证书和医师报告）来验证，以确定家庭历史记录报告的敏感性和特定性。还将收集一些其他流行病学和社会心理变量，以检查报告准确性和完整性的可能预测指标。