NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR

一个综合性口腔健康研究中心的发现（COHRCD）建议在弗朗西斯科的加州大学（UCSF）服务弗朗西斯科和北方加州。本次COHRCD的科学主题是“增强组织完整性和修复的新策略”。“这一主题将从两个互补的角度来探讨：加强对具有发育或后天缺陷的口腔和颅面组织的修复;以及干预以防止这些组织的破坏和退化。这一主题与出生时患有颅面畸形的儿童有关;有患猖獗龋齿风险的幼儿;面部创伤、口腔癌、严重牙周炎和颞下颌关节疾病的人;以及慢性致残性骨骼疾病患者，包括牙槽骨丢失和牙齿丢失、骨关节炎和骨质疏松症。关于组织修复的增强，我们的假设是正常组织分化和成熟的过程以及成功的组织重塑和修复的过程具有重要的机制特征。这个想法是我们希望在一个综合项目中一起研究这些过程的基础，以便发现正常发育和功能的新标志物，以及刺激结缔组织和骨骼组织再生修复的新策略。关于维持组织完整性，提出了积极的诊断、干预和教育外展战略，以减少慢性退行性疾病和病症的发病率和发病率。该中心的具体目标是：（1）支持解决结缔组织和骨骼组织发育和修复机制的基础和面向患者的研究项目。2)支持与维护组织完整性和预防导致组织破坏的疾病、紊乱和行为相关的临床（以患者为导向）研究。3)建立核心设施，为与该委员会有关的项目提供技术服务和资源。5)为培训未来的卫生保健专业人员和科学家提供丰富的环境。6)建立各种机制，包括海湾地区组织工程和修复网络和米尔贝里研讨会方案，以加强人权与发展委员会支持的项目中的调查人员之间的沟通，以及加州北部地区的调查人员与区域工业、地区保健提供者和社区机构之间的沟通。

A Comprehensive Oral Health Research Center of Discovery (COHRCD) is proposed at the University of California, San Francisco (UCSF) to serve San Francisco and Northern California. The scientific theme of this COHRCD is "New Strategies for Enhancing Tissue Integrity and Repair." This theme will be pursued from two complementary points of view: enhancing the repair of oral and craniofacial tissues with developmental or acquired defects: and intervening to prevent the destruction and degeneration of these tissues. This theme has relevance for children born with craniofacial anomalies; young children at risk for rampant caries; people with facial trauma, oral cancer, severe periodontitis and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis. Regarding enhancement of tissue repair, our hypothesis is that the processes of normal tissue differentiation and maturation, and of successful tissue remodeling and repair, share important mechanistic features. This idea underlies our desire to study these processes together in an integrated program so as to uncover novel markers of normal development and function, and novel strategies for stimulating regenerative repair of connective and skeletal tissues. Regarding maintenance of tissue integrity, aggressive diagnostic, interventional and educational outreach strategies to reduce the incidence and morbidity of chronic degenerative diseases and disorders are proposed. The specific aims of this COHRCD are to: 1) Support basic and patient-oriented research projects that address mechanisms of development and repair of connective and skeletal tissues. 2) Support clinical (patient-oriented) research related to the maintenance of tissue integrity and prevention of diseases, disorders and behaviors that result in tissue destruction. 3) Establish core facilities to provide technical services and resources to COHRCD-affiliated projects. 5) Provide an enriched environment for training future health-care professionals and scientists. 6) Establish mechanisms, including the Bay Area Tissue Engineering and Repair Network (BayTERN) and the Millberry Seminars program, to increase communication among investigators in COHRCD-supported projects and between investigators and regional industry, area health-care providers and community institutions in the Norther California region.