NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR

加州大学旧金山分校(UCSF)提议建立一个综合口腔健康研究发现中心(COHRCD)，为旧金山和北加州提供服务。本次COHRCD的科学主题是“增强组织完整性和修复的新策略”。将从两个相辅相成的角度探讨这一主题：加强口腔和头面部发育或后天缺陷组织的修复；以及采取干预措施，防止这些组织的破坏和退化。这一主题适用于出生时患有颅面畸形的儿童；面临严重龋齿风险的幼儿；面部创伤、口腔癌、严重牙周炎和颞下颌关节疾病患者；以及患有慢性致残性骨骼疾病的患者，包括牙槽骨丢失和牙齿丢失、骨关节炎和骨质疏松症。关于促进组织修复，我们的假设是，正常组织分化和成熟的过程，以及成功的组织重塑和修复过程，具有重要的机制特征。这一想法是我们希望在一个综合项目中一起研究这些过程的愿望，以发现正常发育和功能的新标记，以及刺激结缔组织和骨骼组织再生修复的新策略。关于维持组织完整性，提出了积极的诊断、干预和教育推广战略，以减少慢性退行性疾病和障碍的发生率和发病率。COHRCD的具体目标是：1)支持基础和以患者为导向的研究项目，这些项目涉及结缔组织和骨骼组织的发展和修复机制。2)支持与维持组织完整性和预防导致组织破坏的疾病、紊乱和行为有关的临床(以病人为中心)研究。3)建立核心设施，为贸发会议附属项目提供技术服务和资源。5)为培养未来的卫生保健专业人员和科学家提供丰富的环境。6)建立机制，包括湾区组织工程和修复网络(BayTERN)和米尔伯里研讨会计划，以加强COHRCD支持的项目中调查人员之间的沟通，以及调查人员与加州北部地区的地区行业、地区医疗保健提供者和社区机构之间的沟通。

A Comprehensive Oral Health Research Center of Discovery (COHRCD) is proposed at the University of California, San Francisco (UCSF) to serve San Francisco and Northern California. The scientific theme of this COHRCD is "New Strategies for Enhancing Tissue Integrity and Repair." This theme will be pursued from two complementary points of view: enhancing the repair of oral and craniofacial tissues with developmental or acquired defects: and intervening to prevent the destruction and degeneration of these tissues. This theme has relevance for children born with craniofacial anomalies; young children at risk for rampant caries; people with facial trauma, oral cancer, severe periodontitis and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis. Regarding enhancement of tissue repair, our hypothesis is that the processes of normal tissue differentiation and maturation, and of successful tissue remodeling and repair, share important mechanistic features. This idea underlies our desire to study these processes together in an integrated program so as to uncover novel markers of normal development and function, and novel strategies for stimulating regenerative repair of connective and skeletal tissues. Regarding maintenance of tissue integrity, aggressive diagnostic, interventional and educational outreach strategies to reduce the incidence and morbidity of chronic degenerative diseases and disorders are proposed. The specific aims of this COHRCD are to: 1) Support basic and patient-oriented research projects that address mechanisms of development and repair of connective and skeletal tissues. 2) Support clinical (patient-oriented) research related to the maintenance of tissue integrity and prevention of diseases, disorders and behaviors that result in tissue destruction. 3) Establish core facilities to provide technical services and resources to COHRCD-affiliated projects. 5) Provide an enriched environment for training future health-care professionals and scientists. 6) Establish mechanisms, including the Bay Area Tissue Engineering and Repair Network (BayTERN) and the Millberry Seminars program, to increase communication among investigators in COHRCD-supported projects and between investigators and regional industry, area health-care providers and community institutions in the Norther California region.