NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR

加州大学旧金山分校（UCSF）提议建立一个综合性口腔健康发现研究中心（COHRCD），为旧金山和北加州服务。这次COHRCD的科学主题是“增强组织完整性和修复的新策略”。本主题将从两个互补的角度进行探讨：加强口腔和颅面组织发育或获得性缺陷的修复，以及干预以防止这些组织的破坏和退化。这一主题与出生时颅面异常的儿童有关；面临猖獗龋齿风险的幼儿；面部外伤、口腔癌、严重牙周炎、颞下颌关节紊乱者；慢性致残性骨骼疾病患者，包括牙槽骨丢失和牙齿脱落，骨关节炎和骨质疏松症。关于组织修复的增强，我们的假设是正常组织的分化和成熟过程，以及成功的组织重塑和修复，具有重要的机制特征。我们希望通过一个综合项目来研究这些过程，从而发现正常发育和功能的新标记，以及刺激结缔组织和骨骼组织再生修复的新策略。在维持组织完整性方面，提出了积极的诊断、干预和教育推广策略，以减少慢性退行性疾病和失调的发病率和发病率。该COHRCD的具体目标是：1)支持基础和面向患者的研究项目，研究结缔组织和骨骼组织的发育和修复机制。2)支持与维持组织完整性和预防导致组织破坏的疾病、紊乱和行为相关的临床（以患者为导向）研究。3)建立核心设施，为cohrcd下属项目提供技术服务和资源。5)为培训未来的保健专业人员和科学家提供丰富的环境。6)建立包括湾区组织工程和修复网络（BayTERN）和Millberry研讨会计划在内的机制，以增加cohrcd支持项目的研究人员之间以及研究人员与北加州地区的区域工业、地区医疗保健提供者和社区机构之间的沟通。

A Comprehensive Oral Health Research Center of Discovery (COHRCD) is proposed at the University of California, San Francisco (UCSF) to serve San Francisco and Northern California. The scientific theme of this COHRCD is "New Strategies for Enhancing Tissue Integrity and Repair." This theme will be pursued from two complementary points of view: enhancing the repair of oral and craniofacial tissues with developmental or acquired defects: and intervening to prevent the destruction and degeneration of these tissues. This theme has relevance for children born with craniofacial anomalies; young children at risk for rampant caries; people with facial trauma, oral cancer, severe periodontitis and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis. Regarding enhancement of tissue repair, our hypothesis is that the processes of normal tissue differentiation and maturation, and of successful tissue remodeling and repair, share important mechanistic features. This idea underlies our desire to study these processes together in an integrated program so as to uncover novel markers of normal development and function, and novel strategies for stimulating regenerative repair of connective and skeletal tissues. Regarding maintenance of tissue integrity, aggressive diagnostic, interventional and educational outreach strategies to reduce the incidence and morbidity of chronic degenerative diseases and disorders are proposed. The specific aims of this COHRCD are to: 1) Support basic and patient-oriented research projects that address mechanisms of development and repair of connective and skeletal tissues. 2) Support clinical (patient-oriented) research related to the maintenance of tissue integrity and prevention of diseases, disorders and behaviors that result in tissue destruction. 3) Establish core facilities to provide technical services and resources to COHRCD-affiliated projects. 5) Provide an enriched environment for training future health-care professionals and scientists. 6) Establish mechanisms, including the Bay Area Tissue Engineering and Repair Network (BayTERN) and the Millberry Seminars program, to increase communication among investigators in COHRCD-supported projects and between investigators and regional industry, area health-care providers and community institutions in the Norther California region.